Hyperthermic isolated perfusion with low-dose TNFα and doxorubicin in patients with locally advanced soft tissue limb sarcomas

Carlo Ricardo Rossi; M. Foletto; S. Mocellin; P. Pilati; L. Quintieri; G. L. De Salvo; D. Nitti; M. Lise

Hyperthermic isolated perfusion with low-dose TNFα and doxorubicin in patients with locally advanced soft tissue limb sarcomas

Carlo Ricardo Rossi, M. Foletto, S. Mocellin, P. Pilati, L. Quintieri, G. L. De Salvo, D. Nitti, M. Lise

Istituto Oncologico Veneto

Research output: Contribution to journal › Article › peer-review

Abstract

We report here the results of 27 patients who underwent hyperthermic isolated limb perfusion with low-dose TNFα (1 mg) and doxorubicin (8.5 mg/l of limb volume) for locally advanced soft tissue sarcomas. A tumor response was observed in 85% of cases. After a median follow-up of 30 months, limb salvage and local disease control were achieved in 82 and 85% of patients, respectively. Locoregional toxicity was low or mild in 14 patients, while 2 patients had severe limb toxicity. Systemic side effects were negligible. The perfusate/plasma area under the curve (AUC) ratio for TNFα was 56. HILP with low-dose TNFα and DXR proved to be an active neoadjuvant drug regimen against limb-threatening STS.

Original language	English
Pages (from-to)	58-61
Number of pages	4
Journal	Journal of Chemotherapy
Volume	16
Issue number	SUPPL. 5
Publication status	Published - Nov 2004

Keywords

Doxorubicin
Isolated limb perfusion
Locally-advanced soft tissue limb sarcomas
TNFα

ASJC Scopus subject areas

Pharmacology (medical)
Microbiology (medical)

Cite this

Hyperthermic isolated perfusion with low-dose TNFα and doxorubicin in patients with locally advanced soft tissue limb sarcomas. / Rossi, Carlo Ricardo; Foletto, M.; Mocellin, S.; Pilati, P.; Quintieri, L.; De Salvo, G. L.; Nitti, D.; Lise, M.

In: Journal of Chemotherapy, Vol. 16, No. SUPPL. 5, 11.2004, p. 58-61.

Research output: Contribution to journal › Article › peer-review

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abstract = "We report here the results of 27 patients who underwent hyperthermic isolated limb perfusion with low-dose TNFα (1 mg) and doxorubicin (8.5 mg/l of limb volume) for locally advanced soft tissue sarcomas. A tumor response was observed in 85% of cases. After a median follow-up of 30 months, limb salvage and local disease control were achieved in 82 and 85% of patients, respectively. Locoregional toxicity was low or mild in 14 patients, while 2 patients had severe limb toxicity. Systemic side effects were negligible. The perfusate/plasma area under the curve (AUC) ratio for TNFα was 56. HILP with low-dose TNFα and DXR proved to be an active neoadjuvant drug regimen against limb-threatening STS.",

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AU - Rossi, Carlo Ricardo

AU - Foletto, M.

AU - Mocellin, S.

AU - Pilati, P.

AU - Quintieri, L.

AU - De Salvo, G. L.

AU - Nitti, D.

AU - Lise, M.

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AB - We report here the results of 27 patients who underwent hyperthermic isolated limb perfusion with low-dose TNFα (1 mg) and doxorubicin (8.5 mg/l of limb volume) for locally advanced soft tissue sarcomas. A tumor response was observed in 85% of cases. After a median follow-up of 30 months, limb salvage and local disease control were achieved in 82 and 85% of patients, respectively. Locoregional toxicity was low or mild in 14 patients, while 2 patients had severe limb toxicity. Systemic side effects were negligible. The perfusate/plasma area under the curve (AUC) ratio for TNFα was 56. HILP with low-dose TNFα and DXR proved to be an active neoadjuvant drug regimen against limb-threatening STS.

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Hyperthermic isolated perfusion with low-dose TNFα and doxorubicin in patients with locally advanced soft tissue limb sarcomas

Abstract

Keywords

ASJC Scopus subject areas

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