Abstract
This paper reports the case of a 31-year-old woman with hyperthyroidism, increased TSH and thyroid hormone levels, evidence of a pituitary adenoma, hyperprolactinaemia, amenorrhoea, and galactorrhoea. Following trans-sphenoidal pituitary adenomectomy, mild hyperthyroidism and increased TSH and α subunit levels persisted, whereas hyperprolactinaemia, amenorrhoea, and galactorrhoea disappeared. Serum TSH levels were not affected by administration of TRH, metoclopramide, domperidone, l-dopa or somatostatin. Serum TSH chromatography showed a normal pattern. Following a second trans-spenoidal pituitary adenomectomy and radiotherapy, hyperthyroidism disappeared, and the TSH and α subunit levels returned to normal. Light microscopy showed no specific TSH immunostaining although electron microscopy revealed numerous secretory granules alined along the plasma membrane. The post-operative follow-up confirmed the presence of a TSH-secreting pituitary adenoma associated to functional hyperprolactinaemia.
| Original language | English |
|---|---|
| Pages (from-to) | 452-458 |
| Number of pages | 7 |
| Journal | Acta Endocrinologica |
| Volume | 116 |
| Issue number | 4 |
| Publication status | Published - 1987 |
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ASJC Scopus subject areas
- Endocrinology
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Hyperthyroidism due to a thyroid-stimulating hormone (TSH)-secreting pituitary adenoma associated with functional hyperprolactinaemia. A case report. / Savastano, S.; Lombardi, G.; Merola, B.; Miletto, P.; Di Prisco, B.; Manco, A.; Beck-Peccoz, P.; Faglia, G.
In: Acta Endocrinologica, Vol. 116, No. 4, 1987, p. 452-458.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Hyperthyroidism due to a thyroid-stimulating hormone (TSH)-secreting pituitary adenoma associated with functional hyperprolactinaemia. A case report
AU - Savastano, S.
AU - Lombardi, G.
AU - Merola, B.
AU - Miletto, P.
AU - Di Prisco, B.
AU - Manco, A.
AU - Beck-Peccoz, P.
AU - Faglia, G.
PY - 1987
Y1 - 1987
N2 - This paper reports the case of a 31-year-old woman with hyperthyroidism, increased TSH and thyroid hormone levels, evidence of a pituitary adenoma, hyperprolactinaemia, amenorrhoea, and galactorrhoea. Following trans-sphenoidal pituitary adenomectomy, mild hyperthyroidism and increased TSH and α subunit levels persisted, whereas hyperprolactinaemia, amenorrhoea, and galactorrhoea disappeared. Serum TSH levels were not affected by administration of TRH, metoclopramide, domperidone, l-dopa or somatostatin. Serum TSH chromatography showed a normal pattern. Following a second trans-spenoidal pituitary adenomectomy and radiotherapy, hyperthyroidism disappeared, and the TSH and α subunit levels returned to normal. Light microscopy showed no specific TSH immunostaining although electron microscopy revealed numerous secretory granules alined along the plasma membrane. The post-operative follow-up confirmed the presence of a TSH-secreting pituitary adenoma associated to functional hyperprolactinaemia.
AB - This paper reports the case of a 31-year-old woman with hyperthyroidism, increased TSH and thyroid hormone levels, evidence of a pituitary adenoma, hyperprolactinaemia, amenorrhoea, and galactorrhoea. Following trans-sphenoidal pituitary adenomectomy, mild hyperthyroidism and increased TSH and α subunit levels persisted, whereas hyperprolactinaemia, amenorrhoea, and galactorrhoea disappeared. Serum TSH levels were not affected by administration of TRH, metoclopramide, domperidone, l-dopa or somatostatin. Serum TSH chromatography showed a normal pattern. Following a second trans-spenoidal pituitary adenomectomy and radiotherapy, hyperthyroidism disappeared, and the TSH and α subunit levels returned to normal. Light microscopy showed no specific TSH immunostaining although electron microscopy revealed numerous secretory granules alined along the plasma membrane. The post-operative follow-up confirmed the presence of a TSH-secreting pituitary adenoma associated to functional hyperprolactinaemia.
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UR - http://www.scopus.com/inward/citedby.url?scp=0023617157&partnerID=8YFLogxK
M3 - Article
C2 - 3425160
AN - SCOPUS:0023617157
VL - 116
SP - 452
EP - 458
JO - Acta Endocrinologica
JF - Acta Endocrinologica
SN - 0001-5598
IS - 4
ER -