Hyperthyroidism due to a thyroid-stimulating hormone (TSH)-secreting pituitary adenoma associated with functional hyperprolactinaemia. A case report

S. Savastano, G. Lombardi, B. Merola, P. Miletto, B. Di Prisco, A. Manco, P. Beck-Peccoz, G. Faglia

Research output: Contribution to journalArticlepeer-review

Abstract

This paper reports the case of a 31-year-old woman with hyperthyroidism, increased TSH and thyroid hormone levels, evidence of a pituitary adenoma, hyperprolactinaemia, amenorrhoea, and galactorrhoea. Following trans-sphenoidal pituitary adenomectomy, mild hyperthyroidism and increased TSH and α subunit levels persisted, whereas hyperprolactinaemia, amenorrhoea, and galactorrhoea disappeared. Serum TSH levels were not affected by administration of TRH, metoclopramide, domperidone, l-dopa or somatostatin. Serum TSH chromatography showed a normal pattern. Following a second trans-spenoidal pituitary adenomectomy and radiotherapy, hyperthyroidism disappeared, and the TSH and α subunit levels returned to normal. Light microscopy showed no specific TSH immunostaining although electron microscopy revealed numerous secretory granules alined along the plasma membrane. The post-operative follow-up confirmed the presence of a TSH-secreting pituitary adenoma associated to functional hyperprolactinaemia.

Original languageEnglish
Pages (from-to)452-458
Number of pages7
JournalActa Endocrinologica
Volume116
Issue number4
Publication statusPublished - 1987

ASJC Scopus subject areas

  • Endocrinology

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