TY - JOUR
T1 - Hyperthyroidism due to a thyroid-stimulating hormone (TSH)-secreting pituitary adenoma associated with functional hyperprolactinaemia. A case report
AU - Savastano, S.
AU - Lombardi, G.
AU - Merola, B.
AU - Miletto, P.
AU - Di Prisco, B.
AU - Manco, A.
AU - Beck-Peccoz, P.
AU - Faglia, G.
PY - 1987
Y1 - 1987
N2 - This paper reports the case of a 31-year-old woman with hyperthyroidism, increased TSH and thyroid hormone levels, evidence of a pituitary adenoma, hyperprolactinaemia, amenorrhoea, and galactorrhoea. Following trans-sphenoidal pituitary adenomectomy, mild hyperthyroidism and increased TSH and α subunit levels persisted, whereas hyperprolactinaemia, amenorrhoea, and galactorrhoea disappeared. Serum TSH levels were not affected by administration of TRH, metoclopramide, domperidone, l-dopa or somatostatin. Serum TSH chromatography showed a normal pattern. Following a second trans-spenoidal pituitary adenomectomy and radiotherapy, hyperthyroidism disappeared, and the TSH and α subunit levels returned to normal. Light microscopy showed no specific TSH immunostaining although electron microscopy revealed numerous secretory granules alined along the plasma membrane. The post-operative follow-up confirmed the presence of a TSH-secreting pituitary adenoma associated to functional hyperprolactinaemia.
AB - This paper reports the case of a 31-year-old woman with hyperthyroidism, increased TSH and thyroid hormone levels, evidence of a pituitary adenoma, hyperprolactinaemia, amenorrhoea, and galactorrhoea. Following trans-sphenoidal pituitary adenomectomy, mild hyperthyroidism and increased TSH and α subunit levels persisted, whereas hyperprolactinaemia, amenorrhoea, and galactorrhoea disappeared. Serum TSH levels were not affected by administration of TRH, metoclopramide, domperidone, l-dopa or somatostatin. Serum TSH chromatography showed a normal pattern. Following a second trans-spenoidal pituitary adenomectomy and radiotherapy, hyperthyroidism disappeared, and the TSH and α subunit levels returned to normal. Light microscopy showed no specific TSH immunostaining although electron microscopy revealed numerous secretory granules alined along the plasma membrane. The post-operative follow-up confirmed the presence of a TSH-secreting pituitary adenoma associated to functional hyperprolactinaemia.
UR - http://www.scopus.com/inward/record.url?scp=0023617157&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023617157&partnerID=8YFLogxK
M3 - Article
C2 - 3425160
AN - SCOPUS:0023617157
VL - 116
SP - 452
EP - 458
JO - Acta Endocrinologica
JF - Acta Endocrinologica
SN - 0001-5598
IS - 4
ER -