Hypertriglyceridemia and regulation of fibrinolytic activity

Luciana Mussoni, Luisa Mannucci, Marina Sirtori, Marina Camera, Paola Maderna, Luigi Sironi, Elena Tremoli

Research output: Contribution to journalArticlepeer-review


A relation between elevated triglyceride (TG) levels and alterations of the fibrinolytic system has been recognized in studies of patients with coronary heart disease. In this investigation, the total fibrinolytic activity and the levels of specific components of the fibrinolytic system were evaluated in plasma samples from a highly selected group of patients with type IV hyperlipoproteinemia before and after a dietary treatment aimed at reducing TG levels. The fibrinolytic response of type IV patients was comparable to that of normolipidemic subjects, whereas tissue-type plasminogen activator antigen levels before and after venous occlusion (p

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Issue number1
Publication statusPublished - 1992


  • Endothelial cells
  • Fibrinolytic activity
  • HepG2 cells
  • Hypertriglyceridemia
  • Plasminogen activator inhibitor-1
  • Tissue-type plasminogen activator
  • Very low density lipoproteins

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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