Abstract
Hyperuricemia is associated with hypertension, kidney disease, vascular and cardiovascular (CV) events. In experimental models, the inhibition of hepatic uricase induces hyperuricemia, hypertension and mild renal disease. Notably, the micro-and macrovascular changes observed in the experimental model of hyperuricemia resemble the histological changes of human hypertension.This paper presents and discusses the epidemiological correlation between high serum uric acid levels and hypertension, and reviews current evidence supporting the protective effects of the normalization of uric acid levels.This review is based on a PubMed/Embase database search for articles on hyperuricemia and its impact on cardiovascular and renal function.
| Original language | English |
|---|---|
| Pages (from-to) | 15-19 |
| Number of pages | 5 |
| Journal | Current Medical Research and Opinion |
| Volume | 31 |
| DOIs | |
| Publication status | Published - Sep 30 2015 |
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Keywords
- Gout
- Hypertension
- Hyperuricemia
- Kidney disease
ASJC Scopus subject areas
- Medicine(all)
Cite this
Hyperuricemia, urate deposition and the association with hypertension. / Mancia, G.; Grassi, G.; Borghi, C.
In: Current Medical Research and Opinion, Vol. 31, 30.09.2015, p. 15-19.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hyperuricemia, urate deposition and the association with hypertension
AU - Mancia, G.
AU - Grassi, G.
AU - Borghi, C.
PY - 2015/9/30
Y1 - 2015/9/30
N2 - Hyperuricemia is associated with hypertension, kidney disease, vascular and cardiovascular (CV) events. In experimental models, the inhibition of hepatic uricase induces hyperuricemia, hypertension and mild renal disease. Notably, the micro-and macrovascular changes observed in the experimental model of hyperuricemia resemble the histological changes of human hypertension.This paper presents and discusses the epidemiological correlation between high serum uric acid levels and hypertension, and reviews current evidence supporting the protective effects of the normalization of uric acid levels.This review is based on a PubMed/Embase database search for articles on hyperuricemia and its impact on cardiovascular and renal function.
AB - Hyperuricemia is associated with hypertension, kidney disease, vascular and cardiovascular (CV) events. In experimental models, the inhibition of hepatic uricase induces hyperuricemia, hypertension and mild renal disease. Notably, the micro-and macrovascular changes observed in the experimental model of hyperuricemia resemble the histological changes of human hypertension.This paper presents and discusses the epidemiological correlation between high serum uric acid levels and hypertension, and reviews current evidence supporting the protective effects of the normalization of uric acid levels.This review is based on a PubMed/Embase database search for articles on hyperuricemia and its impact on cardiovascular and renal function.
KW - Gout
KW - Hypertension
KW - Hyperuricemia
KW - Kidney disease
UR - http://www.scopus.com/inward/record.url?scp=84942609449&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942609449&partnerID=8YFLogxK
U2 - 10.1185/03007995.2015.1087981
DO - 10.1185/03007995.2015.1087981
M3 - Article
C2 - 26414732
AN - SCOPUS:84942609449
VL - 31
SP - 15
EP - 19
JO - Current Medical Research and Opinion
JF - Current Medical Research and Opinion
SN - 0300-7995
ER -