Hyperventilation in normal subjects. A clinical, gas-analytic and EMG study

P. Montagna, M. Paniccia, L. Marchello, R. Riva

Research output: Contribution to journalArticlepeer-review


Clinical (paresthesiae and Trousseau's sign), EMG, blood biochemical (lactic acid and total Ca2+) and gas-analytic (pH, PCO2, Poll HCO3) changes were studied during and after 5 min voluntary hyperventilation (HV) in 15 normal subjects. Paresthesiae and spontaneous motor activity were common manifestations (87% and 67% respectively) in our test. They were significantly related only to changes in pH, PCO2 and PO2, with paresthesiae arising earlier and at milder gas-analytic changes than motor activity. Paresthesiae and motor activity induced by HV cannot be used as reliable indicators of pathology. Their presence simply reflects the degree of the blood gas-analytic changes (pH, PCO2 and PO2) which therefore should be carefully monitored before drawing any conclusion from an HV test.

Original languageEnglish
Pages (from-to)159-163
Number of pages5
JournalElectroencephalography and Clinical Neurophysiology - Electromyography and Motor Control
Issue number3
Publication statusPublished - 1995


  • EMG
  • Hyperventilation
  • Hypocapnia
  • Paresthesia
  • Repetitive EMG activity
  • Trousseau's sign

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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