Hypnotic modulation of pain perception and of brain activity triggered by nociceptive laser stimuli

Elia Valentini, Viviana Betti, Li Hu, Salvatore M. Aglioti

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Introduction: Neuroimaging studies indicate that hypnotic suggestions of increased and decreased pain intensity and unpleasantness may modulate somatosensory and cingulate cortex activity, respectively. Methods: Using a within subject design and a strict subject selection procedure, we tested in High (Highs) and Low (Lows) hypnotically suggestible individuals whether hypnotic suggestions of sensory and affective hypoalgesia or hyperalgesia differentially affected subjective ratings of laser-induced pain and nociceptive-related brain activity in the time- and time-frequency domain. Results: Hypnotic modulation of pain intensity and unpleasantness affected subjective ratings of laser-induced pain only in Highs. Such modulation was more specific for unpleasantness manipulation and more evident for suggestions of hyperalgesia. Importantly, Highs and Lows showed increase and decrease of P2a and P2b wave amplitudes and gamma band power, respectively. Conclusions: Hypnotic suggestions exerted a top-down modulatory effect on both evoked and induced-cortical brain responses triggered by selective nociceptive laser inputs. Furthermore, correlation analyses indicated that gamma power modulation and suggestions of hyperalgesia may reflect the process of allocating control resources to salient and threatening sensory-affective dimensions of pain.

Original languageEnglish
Pages (from-to)446-462
Number of pages17
JournalCortex
Volume49
Issue number2
DOIs
Publication statusPublished - Feb 2013

Fingerprint

Pain Perception
Suggestion
Hypnotics and Sedatives
Hyperalgesia
Lasers
Pain
Brain
Nociceptive Pain
Somatosensory Cortex
Gyrus Cinguli
Neuroimaging
Patient Selection
Modulation
Laser
Stimulus
Power (Psychology)

Keywords

  • Cingulate cortex
  • Hypnosis
  • Laser-evoked potentials (LEPs)
  • Nociception
  • Posterior parietal cortex

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

Cite this

Hypnotic modulation of pain perception and of brain activity triggered by nociceptive laser stimuli. / Valentini, Elia; Betti, Viviana; Hu, Li; Aglioti, Salvatore M.

In: Cortex, Vol. 49, No. 2, 02.2013, p. 446-462.

Research output: Contribution to journalArticle

Valentini, Elia ; Betti, Viviana ; Hu, Li ; Aglioti, Salvatore M. / Hypnotic modulation of pain perception and of brain activity triggered by nociceptive laser stimuli. In: Cortex. 2013 ; Vol. 49, No. 2. pp. 446-462.
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