Hypoalbuminemia as a predictor of acute kidney injury during colistin treatment

Daniele Roberto Giacobbe, Alessandra di Masi, Loris Leboffe, Valerio Del Bono, Marianna Rossi, Dario Cappiello, Erika Coppo, Anna Marchese, Annarita Casulli, Alessio Signori, Andrea Novelli, Katja Perrone, Luigi Principe, Alessandra Bandera, Luca Enrico Vender, Andrea Misin, Pierpaolo Occhilupo, Marcello Melone, Paolo Ascenzi, Andrea GoriRoberto Luzzati, Claudio Viscoli, Stefano Di Bella

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This study aimed to assess the predictors of acute kidney injury (AKI) during colistin therapy in a cohort of patients with bloodstream infections (BSI) due to colistin-susceptible Gram-negative bacteria, focusing on the role of serum albumin levels. The study consisted of two parts: (1) a multicentre retrospective clinical study to assess the predictors of AKI during colistin therapy, defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) criteria; and (2) bioinformatic and biochemical characterization of the possible interaction between human serum albumin and colistin. Among the 170 patients included in the study, 71 (42%), 35 (21%), and 11 (6%) developed KDIGO stage 1 (K1-AKI), KDIGO stage 2 (K2-AKI), and KDIGO stage 3 (K3-AKI), respectively. In multivariable analyses, serum albumin <2.5 g/dL was independently associated with K1-AKI (subdistribution hazard ratio [sHR] 1.85, 95% confidence interval [CI] 1.17–2.93, p = 0.009) and K2-AKI (sHR 2.37, 95% CI 1.15–4.87, p = 0.019). Bioinformatic and biochemical analyses provided additional information nurturing the discussion on how hypoalbuminemia favors development of AKI during colistin therapy. In conclusion, severe hypoalbuminemia independently predicted AKI during colistin therapy in a large cohort of patients with BSI due to colistin-susceptible Gram-negative bacteria. Further study is needed to clarify the underlying causal pathways.

Original languageEnglish
Article number11968
JournalScientific Reports
Issue number1
Publication statusPublished - Dec 1 2018

ASJC Scopus subject areas

  • General


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