Hypofractionated radiotherapy with or without IGRT in prostate cancer: Preliminary report of acute toxicity

Maurizio Valeriani, Flavia Monaco, Mattia Falchetto Osti, Vitaliana De Sanctis, Giuseppe Minniti, Riccardo Maurizi Enrici

Research output: Contribution to journalArticlepeer-review


Background: To evaluate the acute tolerance to hypofractionated schedule of patients with prostate cancer. Patients and Methods: We treated 62 patients with intermediate risk prostate cancer. All patients were treated with a total dose of 43.8 Gy on seminal vesicles and 54.75 Gy on prostate, 3.65 Gy per fraction, three times a week for a total of 5 weeks. All patients underwent neoadjuvant, concomitant and adjuvant hormonal therapy. Thirty-six patients were submitted to image-guided radiation therapy (IGRT). Results: Median follow-up was 15 months (range 3-33 months). Toxicities during the treatment were: grade 1-2 gastrointestinal (GI) toxicity, 22.6%; grade 1-2 genitourinary (GU) toxicity, 51.6%. Toxicities 3 months after the end of the treatment were grade 1-2 GI 6.5%, grade 1-2 GU 9.7%. No statistical difference was observed comparing acute toxicity in patients treated with or without IGRT. Conclusion: This study showed that the hypofractionation schedule used is well tolerated, with a low rate of acute grade 1-2 GI toxicity and without major grade (≥3) acute toxicity. Longer follow-up is needed to determine if this low rate of acute toxicity will be translated in a low rate of late toxicity.

Original languageEnglish
Pages (from-to)3555-3558
Number of pages4
JournalAnticancer Research
Issue number10
Publication statusPublished - Oct 2011


  • Acute effect
  • Hormonotherapy
  • Hypofractionated radiotherapy
  • Image guided radiation therapy
  • Intermediate risk
  • Prostate cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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