Hypofractionated stereotactic radiotherapy for oligometastases in the brain: A single-institution experience

Marcello Marchetti, Ida Milanesi, Chiara Falcone, Michela De Santis, Luisa Fumagalli, Lorenzo Brait, Livia Bianchi, Laura Fariselli

Research output: Contribution to journalArticlepeer-review


The treatment of brain metastases is changing. Many different radiotherapy options are now available and under clinical evaluation. As part of this effort, we retrospectively evaluated the efficacy and toxicity of hypofractionated stereotactic radiotherapy (HSRT) in patients with up to three brain metastases. Sixty-five patients with 81 lesions were treated with hypofractionated radiotherapy. Median dose was 24 Gy in three fractions. Median followup was 24.6 months. Actuarial tumour control was 75 and 45% at 9 months and 24 months after treatment, respectively. Median survival time was 7.5 months, and 32% of the patients died from brain tumour progression. Actuarial overall survival was 75% at 3 months and 25% at 12 months. Recursive partitioning analysis class was the only significant prognostic factor. Neoadjuvant wholebrain radiotherapy (in 29 patients) had no impact on survival or local control. Neurological status improved in 42 patients (65%). Adverse events were rare and usually mild. This experience suggests HSRT should be considered as an alternative approach in the treatment of one to three metastatic lesions in selected patients.

Original languageEnglish
Pages (from-to)393-399
Number of pages7
JournalNeurological Sciences
Issue number3
Publication statusPublished - Jun 2011


  • Cerebral oligometastases
  • Hypofractionated stereotactic radiotherapy
  • Whole-brain radiotherapy

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Dermatology


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