La ipoglicorrachia quale possibile indice precoce di infezione del sistema nervoso centrale da parte dell'HIV.

M. Farinelli; M. Camera; V. Del Bono; M. A. Fiorelli; C. Panavese; F. Valguarnera

La ipoglicorrachia quale possibile indice precoce di infezione del sistema nervoso centrale da parte dell'HIV.

Translated title of the contribution: Hypoglycorrhachia as an early sign of central nervous system infection caused by HIV

M. Farinelli, M. Camera, V. Del Bono, M. A. Fiorelli, C. Panavese, F. Valguarnera

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Cerebrospinal fluid (CSP) glucose values were measured in 37 HIV-positive patients with neurologic symptoms and in 35 HIV-negative controls affected by bacterial or viral meningo-encephalitis (ME). Low CSF glucose values were found more frequently in HIV+ patients (49% of cases) than in ME patients (14%). CSF/serum ratios for glucose were also significantly lower in HIV +. Mean serum glucose did not differ between the two groups. Since HIV is a strongly neurotropic and infects early the endothelial cells of the brain capillaris, where glucose is actively carried from plasma to CSP, it is hypothesized that low CSF glucose in HIV-infected patients with neurological symptoms might be an early sign of CNS invasion by the virus.

Translated title of the contribution	Hypoglycorrhachia as an early sign of central nervous system infection caused by HIV
Original language	Italian
Pages (from-to)	44-45
Number of pages	2
Journal	Medicina - Rivista della Enciclopedia Medica Italiana
Volume	9
Issue number	1
Publication status	Published - Jan 1989

ASJC Scopus subject areas

Medicine(all)

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title = "La ipoglicorrachia quale possibile indice precoce di infezione del sistema nervoso centrale da parte dell'HIV.",

abstract = "Cerebrospinal fluid (CSP) glucose values were measured in 37 HIV-positive patients with neurologic symptoms and in 35 HIV-negative controls affected by bacterial or viral meningo-encephalitis (ME). Low CSF glucose values were found more frequently in HIV+ patients (49% of cases) than in ME patients (14%). CSF/serum ratios for glucose were also significantly lower in HIV +. Mean serum glucose did not differ between the two groups. Since HIV is a strongly neurotropic and infects early the endothelial cells of the brain capillaris, where glucose is actively carried from plasma to CSP, it is hypothesized that low CSF glucose in HIV-infected patients with neurological symptoms might be an early sign of CNS invasion by the virus.",

author = "M. Farinelli and M. Camera and {Del Bono}, V. and Fiorelli, {M. A.} and C. Panavese and F. Valguarnera",

year = "1989",

month = jan,

language = "Italian",

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pages = "44--45",

journal = "Medicina - Rivista della Enciclopedia Medica Italiana",

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T1 - La ipoglicorrachia quale possibile indice precoce di infezione del sistema nervoso centrale da parte dell'HIV.

AU - Farinelli, M.

AU - Camera, M.

AU - Del Bono, V.

AU - Fiorelli, M. A.

AU - Panavese, C.

AU - Valguarnera, F.

PY - 1989/1

Y1 - 1989/1

N2 - Cerebrospinal fluid (CSP) glucose values were measured in 37 HIV-positive patients with neurologic symptoms and in 35 HIV-negative controls affected by bacterial or viral meningo-encephalitis (ME). Low CSF glucose values were found more frequently in HIV+ patients (49% of cases) than in ME patients (14%). CSF/serum ratios for glucose were also significantly lower in HIV +. Mean serum glucose did not differ between the two groups. Since HIV is a strongly neurotropic and infects early the endothelial cells of the brain capillaris, where glucose is actively carried from plasma to CSP, it is hypothesized that low CSF glucose in HIV-infected patients with neurological symptoms might be an early sign of CNS invasion by the virus.

AB - Cerebrospinal fluid (CSP) glucose values were measured in 37 HIV-positive patients with neurologic symptoms and in 35 HIV-negative controls affected by bacterial or viral meningo-encephalitis (ME). Low CSF glucose values were found more frequently in HIV+ patients (49% of cases) than in ME patients (14%). CSF/serum ratios for glucose were also significantly lower in HIV +. Mean serum glucose did not differ between the two groups. Since HIV is a strongly neurotropic and infects early the endothelial cells of the brain capillaris, where glucose is actively carried from plasma to CSP, it is hypothesized that low CSF glucose in HIV-infected patients with neurological symptoms might be an early sign of CNS invasion by the virus.

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