Hypogonadotrophic pituitary insufficiency in transfusional hemochromatosis complicating thalassemia major: MR imaging

G. Sparacia, A. Banco, M. Midiri, P. D'Angelo, A. Luca, G. Brancatelli, A. Caronia, R. Lagalla

Research output: Contribution to journalArticle

Abstract

To identify pituitary iron overload in patients with transfusion- dependent thalassemia major causing secondary hypogonadism, we prospectively evaluated signal intensity abnormalities of the anterior lobe of the pituitary gland of 30 patients comparing spin-echo, gradient-echo imaging and pituitary T2 relaxation times measurement. We found that pituitary iron overload can best be assessed by MR imaging using gradient-echo T2*-weighted technique to establish signal reduction in the anterior lobe of the pituitary gland. This finding is correlated to increasing serum ferritin level - a parameter that reflects the severity of iron overload, and is more evident in patients with secondary hypogonadism. This finding is consistent with the hypothesis of hypogonadotrophic pituitary insufficiency due to iron-induced cellular damage.

Original languageEnglish
Pages (from-to)109-111
Number of pages3
JournalRivista di Neuroradiologia
Volume12
Issue numberSUPPL. 2
Publication statusPublished - 1999

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Hypopituitarism
Anterior Pituitary Gland
Hemochromatosis
beta-Thalassemia
Iron Overload
Hypogonadism
Ferritins
Iron
Serum

Keywords

  • Hemocromatosis
  • MRI
  • Pituitary
  • Thalassemia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

Cite this

Sparacia, G., Banco, A., Midiri, M., D'Angelo, P., Luca, A., Brancatelli, G., ... Lagalla, R. (1999). Hypogonadotrophic pituitary insufficiency in transfusional hemochromatosis complicating thalassemia major: MR imaging. Rivista di Neuroradiologia, 12(SUPPL. 2), 109-111.

Hypogonadotrophic pituitary insufficiency in transfusional hemochromatosis complicating thalassemia major : MR imaging. / Sparacia, G.; Banco, A.; Midiri, M.; D'Angelo, P.; Luca, A.; Brancatelli, G.; Caronia, A.; Lagalla, R.

In: Rivista di Neuroradiologia, Vol. 12, No. SUPPL. 2, 1999, p. 109-111.

Research output: Contribution to journalArticle

Sparacia, G, Banco, A, Midiri, M, D'Angelo, P, Luca, A, Brancatelli, G, Caronia, A & Lagalla, R 1999, 'Hypogonadotrophic pituitary insufficiency in transfusional hemochromatosis complicating thalassemia major: MR imaging', Rivista di Neuroradiologia, vol. 12, no. SUPPL. 2, pp. 109-111.
Sparacia, G. ; Banco, A. ; Midiri, M. ; D'Angelo, P. ; Luca, A. ; Brancatelli, G. ; Caronia, A. ; Lagalla, R. / Hypogonadotrophic pituitary insufficiency in transfusional hemochromatosis complicating thalassemia major : MR imaging. In: Rivista di Neuroradiologia. 1999 ; Vol. 12, No. SUPPL. 2. pp. 109-111.
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