Abstract
To identify pituitary iron overload in patients with transfusion- dependent thalassemia major causing secondary hypogonadism, we prospectively evaluated signal intensity abnormalities of the anterior lobe of the pituitary gland of 30 patients comparing spin-echo, gradient-echo imaging and pituitary T2 relaxation times measurement. We found that pituitary iron overload can best be assessed by MR imaging using gradient-echo T2*-weighted technique to establish signal reduction in the anterior lobe of the pituitary gland. This finding is correlated to increasing serum ferritin level - a parameter that reflects the severity of iron overload, and is more evident in patients with secondary hypogonadism. This finding is consistent with the hypothesis of hypogonadotrophic pituitary insufficiency due to iron-induced cellular damage.
| Original language | English |
|---|---|
| Pages (from-to) | 109-111 |
| Number of pages | 3 |
| Journal | Rivista di Neuroradiologia |
| Volume | 12 |
| Issue number | SUPPL. 2 |
| Publication status | Published - 1999 |
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Keywords
- Hemocromatosis
- MRI
- Pituitary
- Thalassemia
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Clinical Neurology
- Radiological and Ultrasound Technology
Cite this
Hypogonadotrophic pituitary insufficiency in transfusional hemochromatosis complicating thalassemia major : MR imaging. / Sparacia, G.; Banco, A.; Midiri, M.; D'Angelo, P.; Luca, A.; Brancatelli, G.; Caronia, A.; Lagalla, R.
In: Rivista di Neuroradiologia, Vol. 12, No. SUPPL. 2, 1999, p. 109-111.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hypogonadotrophic pituitary insufficiency in transfusional hemochromatosis complicating thalassemia major
T2 - MR imaging
AU - Sparacia, G.
AU - Banco, A.
AU - Midiri, M.
AU - D'Angelo, P.
AU - Luca, A.
AU - Brancatelli, G.
AU - Caronia, A.
AU - Lagalla, R.
PY - 1999
Y1 - 1999
N2 - To identify pituitary iron overload in patients with transfusion- dependent thalassemia major causing secondary hypogonadism, we prospectively evaluated signal intensity abnormalities of the anterior lobe of the pituitary gland of 30 patients comparing spin-echo, gradient-echo imaging and pituitary T2 relaxation times measurement. We found that pituitary iron overload can best be assessed by MR imaging using gradient-echo T2*-weighted technique to establish signal reduction in the anterior lobe of the pituitary gland. This finding is correlated to increasing serum ferritin level - a parameter that reflects the severity of iron overload, and is more evident in patients with secondary hypogonadism. This finding is consistent with the hypothesis of hypogonadotrophic pituitary insufficiency due to iron-induced cellular damage.
AB - To identify pituitary iron overload in patients with transfusion- dependent thalassemia major causing secondary hypogonadism, we prospectively evaluated signal intensity abnormalities of the anterior lobe of the pituitary gland of 30 patients comparing spin-echo, gradient-echo imaging and pituitary T2 relaxation times measurement. We found that pituitary iron overload can best be assessed by MR imaging using gradient-echo T2*-weighted technique to establish signal reduction in the anterior lobe of the pituitary gland. This finding is correlated to increasing serum ferritin level - a parameter that reflects the severity of iron overload, and is more evident in patients with secondary hypogonadism. This finding is consistent with the hypothesis of hypogonadotrophic pituitary insufficiency due to iron-induced cellular damage.
KW - Hemocromatosis
KW - MRI
KW - Pituitary
KW - Thalassemia
UR - http://www.scopus.com/inward/record.url?scp=0032910219&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032910219&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0032910219
VL - 12
SP - 109
EP - 111
JO - Rivista di Neuroradiologia
JF - Rivista di Neuroradiologia
SN - 1120-9976
IS - SUPPL. 2
ER -