Hypolipaemic and haemorheologic effects of coenzyme a (CoAlip* * CoAlip, ISF SpA, Trezzano S.N., Milan, Italy.) in patients with various types of dyslipidaemia

E. Altomare, N. Stufano, G. L. Vendemiale, O. Albano, G. Fraticelli

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Abstract

Twenty-two patients with cholesterotaemia and/or triglyceridaemia with blood lipid values exceeding normal (dyslipoproteinaemia Types IIa, IIb and IV) were treated for 20 days with Coenzyme A (CoA), given intravenously as a single daily dose of 2000 Lipmann Units. The aim of the study was to determine whether CoA reduced lipidaemic values in dyslipoproteinaemic patients, and whether this reduction was accompanied by improved erythrocyte shape flexibility as measured by Reid's test. The results of the study confirm that the normalizing effect of CoA is evenly spread among all the parameters of modified lipid metabolism, the time between administration and onset of activity being short. CoA therapy also resulted in greater erythrocyte shape flexibility in the patients examined, consequently with enhanced tissue oxygenation. No side-effects were recorded, confirming that the tolerability of CoA, a physiological substance, is excellent.

Original languageEnglish
Pages (from-to)254-264
Number of pages11
JournalClinical Trials Journal
Volume24
Issue number3
Publication statusPublished - 1987

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Keywords

  • Coenzyme A
  • Dyslipoproteinaemia
  • erythrocyte shape flexibility
  • Reid's test

ASJC Scopus subject areas

  • Pharmacology (medical)

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