Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies

Vincenzo Mollace, Iolanda Sacco, Elzbieta Janda, Claudio Malara, Domenica Ventrice, Carmen Colica, Valeria Visalli, Saverio Muscoli, Salvatore Ragusa, Carolina Muscoli, Domenicantonio Rotiroti, Franco Romeo

Research output: Contribution to journalArticle

Abstract

Bergamot juice produces hypolipemic activity in rats though the mechanism remains unclear. Here we investigated on the effect of bergamot extract (BPF) in diet-induced hyperlipemia in Wistar rats and in 237 patients suffering from hyperlipemia either associated or not with hyperglycaemia. BPF, given orally for 30 days to both rats and patients, reduces total and LDL cholesterol levels (an effect accompanied by elevation of cHDL), triglyceride levels and by a significant decrease in blood glucose. Moreover, BPF inhibited HMG-CoA reductase activity and enhanced reactive vasodilation thus representing an efficient phytotherapeutic approach in combating hyperlipemic and hyperglycaemic disorders.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalFitoterapia
Volume82
Issue number3
DOIs
Publication statusPublished - Apr 2011

Keywords

  • Bergamot
  • CVD prevention
  • Dyslipidemia
  • Flavanones
  • Metabolism
  • Vasodilation

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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    Mollace, V., Sacco, I., Janda, E., Malara, C., Ventrice, D., Colica, C., Visalli, V., Muscoli, S., Ragusa, S., Muscoli, C., Rotiroti, D., & Romeo, F. (2011). Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies. Fitoterapia, 82(3), 309-316. https://doi.org/10.1016/j.fitote.2010.10.014