Hypomelanosis of Ito: A syndrome requiring a multisystem approach

Pinella Failla, Corrado Romano, Carmelo Schepis

Research output: Contribution to journalArticlepeer-review


Hypomelanosis of Ito can be defined as a syndrome providing a cutaneous epiphenomenon with a peculiar pattern of distribution, usually associated with disorders of the nervous system, skeleton and eyes. Four further patients are reported and the literature reviewed. The diagnostic criteria and the differences with other pigmentary diseases distributed along Blasehko's lines are highlighted. The main histopathological features are reported and the high frequency of the associated abnormalities are emphasized. The chromosomal findings and main genetic hypotheses are discussed. The suggested follow-up aims not only at the knowledge of the natural history of this condition, but also at its better delineation.

Original languageEnglish
Pages (from-to)65-70
Number of pages6
JournalAustralasian Journal of Dermatology
Issue number2
Publication statusPublished - 1997


  • Blasehko lines
  • genetic heterogeneity
  • Incontinentia pigmenti achromians
  • neurocutaneous syndrome

ASJC Scopus subject areas

  • Dermatology


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