Hyponatremia in cancer patients

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Hyponatremia is the most frequent electrolyte disorder in hospitalized patients but also a well-known poor prognostic factor in cancer patients. The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is often misdiagnosed by oncologists because of difficulties in the interpretation of laboratory tests. The etiology of hyponatremia is heterogeneous, but the predominant cause is an imbalance between excessive presence of water and serum sodium deficiency. Ectopic production of arginine vasopressin develops most frequently in small cell lung cancer, but also occurs in other malignancies. Neurological impairment may range from subclinical to life-threatening symptoms depending on the rate of serum sodium deficiency. Accurate diagnosis is essential to establish the appropriate therapy. When hyponatremia is caused by SIADH, hypertonic saline infusion is indicated for acute presentations whereas fluid restriction is preferred in cases of an asymptomatic chronic evolution. Other options include vasopressin receptor antagonists ("vaptans") targeted specifically to the correction of euvolemic hyponatremia. The aim of this brief report is to provide concise and specific information for the management of SIADH in clinical practice in oncology.

Original languageEnglish
Pages (from-to)246-248
Number of pages3
JournalTumori
Volume101
Issue number2
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Hyponatremia
Vasopressins
Neoplasms
Sodium
Inappropriate ADH Syndrome
Information Management
Arginine Vasopressin
Small Cell Lung Carcinoma
Diagnostic Errors
Serum
Electrolytes
Water
Therapeutics

Keywords

  • Hyponatremia
  • Lung Cancer
  • SIADH

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Medicine(all)

Cite this

Hyponatremia in cancer patients. / Platania, Marco; Verzoni, Elena; Vitali, Milena.

In: Tumori, Vol. 101, No. 2, 01.03.2015, p. 246-248.

Research output: Contribution to journalArticle

Platania, Marco ; Verzoni, Elena ; Vitali, Milena. / Hyponatremia in cancer patients. In: Tumori. 2015 ; Vol. 101, No. 2. pp. 246-248.
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