Hyponatremic-hypertensive syndrome with extensive and reversible renal defects

Antonella Trivelli, Gian Marco Ghiggeri, Alberto Canepa, Mauro Oddone, Gianlauro Bava, Francesco Perfumo

Research output: Contribution to journalArticlepeer-review


Two young children with renal artery stenosis and severe hypertension who presented with the so-called hyponatremic-hypertensive syndrome (HHS), with marked urine and solute loss during the acute phase, are described. Both children also presented with severe high molecular proteinuria, glycosuria, and hypercalciuria, only the first symptom having prompt remission after normalization of blood pressure. In children with renal artery stenosis, HHS is associated with severe proteinuria due to hyperfiltration and more extensive tubular functional alterations. Hyponatremia and acute tubulopathy may mask the presenting clinical picture of renal artery stenosis.

Original languageEnglish
Pages (from-to)102-104
Number of pages3
JournalPediatric Nephrology
Issue number1
Publication statusPublished - Jan 2005


  • Hypertension
  • Hyponatremic-hypertensive syndrome
  • Proteinuria
  • Renal artery stenosis
  • Renal salt wasting

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health


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