Abstract
Hypoparathyroidism is a rare disease characterized by low serum calcium levels and absent or deficient parathyroid hormone level. Regarding the epidemiology of chronic hypoparathyroidism, there are limited data in Italy and worldwide. Therefore, the purpose of this study was to build a unique database of patients with chronic hypoparathyroidism, derived from the databases of 16 referral centers for endocrinological diseases, affiliated with the Italian Society of Endocrinology, and four centers for endocrine surgery with expertise in hypoparathyroidism, to conduct an epidemiological analysis of chronic hypoparathyroidism in Italy. The study was approved by the Institutional Review Board. A total of 537 patients with chronic hypoparathyroidism were identified. The leading etiology was represented by postsurgical hypoparathyroidism (67.6%), followed by idiopathic hypoparathyroidism (14.6%), syndromic forms of genetic hypoparathyroidism (11%), forms of defective PTH action (5.2%), non-syndromic forms of genetic hypoparathyroidism (0.9%), and, finally, other forms of acquired hypoparathyroidism, due to infiltrative diseases, copper or iron overload, or ionizing radiation exposure (0.7%). This study represents one of the first large-scale epidemiological assessments of chronic hypoparathyroidism based on data collected at medical and/or surgical centers with expertise in hypoparathyroidism in Italy. Although the study presents some limitations, it introduces the possibility of a large-scale national survey, with the final aim of defining not only the prevalence of chronic hypoparathyroidism in Italy, but also standards for clinical and therapeutic approaches.
| Original language | English |
|---|---|
| Pages (from-to) | 151-163 |
| Journal | Calcified Tissue International |
| Volume | 103 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2018 |
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Keywords
- Epidemiology
- Hypoparathyroidism
- Parathyroid hormone
- Therapy
- Thyroidectomy
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Orthopedics and Sports Medicine
- Endocrinology
Cite this
HypoparaNet : A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy. / Marcucci, Gemma; Cianferotti, Luisella; Parri, Simone; Altieri, Paola; Arvat, Emanuela; Benvenga, Salvatore; Betterle, Corrado; Bondanelli, Marta; Boscaro, Marco; Camozzi, Valentina; Centaro, Grazia Maria; Cetani, Filomena; Chiodini, Iacopo; Ciampolillo, Anna; Colao, Annamaria; Corbetta, Sabrina; De Feo, Maria Laura; Uberti, Ettore degli; Faggiano, Antongiulio; Fornari, Rachele; Gaspari, Achille Lucio; Giorgino, Francesco; Giuliani, Valeria; Iacobone, Maurizio; Innaro, Nadia; Lamacchia, Olga; Lenzi, Andrea; Mantovani, Giovanna; Marcocci, Claudio; Masi, Laura; Migliaccio, Silvia; Palmieri, Serena; Pasquali, Renato; Perigli, Giuliano; Piccini, Valentina; Romagnoli, Elisabetta; Ruggeri, Rosaria Maddalena; Rulli, Francesco; Samà, Maria Teresa; Tomaino, Giuseppe; Trimarchi, Francesco; Zatelli, Maria Chiara; Brandi, Maria Luisa.
In: Calcified Tissue International, Vol. 103, No. 2, 2018, p. 151-163.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - HypoparaNet
T2 - A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy
AU - Marcucci, Gemma
AU - Cianferotti, Luisella
AU - Parri, Simone
AU - Altieri, Paola
AU - Arvat, Emanuela
AU - Benvenga, Salvatore
AU - Betterle, Corrado
AU - Bondanelli, Marta
AU - Boscaro, Marco
AU - Camozzi, Valentina
AU - Centaro, Grazia Maria
AU - Cetani, Filomena
AU - Chiodini, Iacopo
AU - Ciampolillo, Anna
AU - Colao, Annamaria
AU - Corbetta, Sabrina
AU - De Feo, Maria Laura
AU - Uberti, Ettore degli
AU - Faggiano, Antongiulio
AU - Fornari, Rachele
AU - Gaspari, Achille Lucio
AU - Giorgino, Francesco
AU - Giuliani, Valeria
AU - Iacobone, Maurizio
AU - Innaro, Nadia
AU - Lamacchia, Olga
AU - Lenzi, Andrea
AU - Mantovani, Giovanna
AU - Marcocci, Claudio
AU - Masi, Laura
AU - Migliaccio, Silvia
AU - Palmieri, Serena
AU - Pasquali, Renato
AU - Perigli, Giuliano
AU - Piccini, Valentina
AU - Romagnoli, Elisabetta
AU - Ruggeri, Rosaria Maddalena
AU - Rulli, Francesco
AU - Samà, Maria Teresa
AU - Tomaino, Giuseppe
AU - Trimarchi, Francesco
AU - Zatelli, Maria Chiara
AU - Brandi, Maria Luisa
PY - 2018
Y1 - 2018
N2 - Hypoparathyroidism is a rare disease characterized by low serum calcium levels and absent or deficient parathyroid hormone level. Regarding the epidemiology of chronic hypoparathyroidism, there are limited data in Italy and worldwide. Therefore, the purpose of this study was to build a unique database of patients with chronic hypoparathyroidism, derived from the databases of 16 referral centers for endocrinological diseases, affiliated with the Italian Society of Endocrinology, and four centers for endocrine surgery with expertise in hypoparathyroidism, to conduct an epidemiological analysis of chronic hypoparathyroidism in Italy. The study was approved by the Institutional Review Board. A total of 537 patients with chronic hypoparathyroidism were identified. The leading etiology was represented by postsurgical hypoparathyroidism (67.6%), followed by idiopathic hypoparathyroidism (14.6%), syndromic forms of genetic hypoparathyroidism (11%), forms of defective PTH action (5.2%), non-syndromic forms of genetic hypoparathyroidism (0.9%), and, finally, other forms of acquired hypoparathyroidism, due to infiltrative diseases, copper or iron overload, or ionizing radiation exposure (0.7%). This study represents one of the first large-scale epidemiological assessments of chronic hypoparathyroidism based on data collected at medical and/or surgical centers with expertise in hypoparathyroidism in Italy. Although the study presents some limitations, it introduces the possibility of a large-scale national survey, with the final aim of defining not only the prevalence of chronic hypoparathyroidism in Italy, but also standards for clinical and therapeutic approaches.
AB - Hypoparathyroidism is a rare disease characterized by low serum calcium levels and absent or deficient parathyroid hormone level. Regarding the epidemiology of chronic hypoparathyroidism, there are limited data in Italy and worldwide. Therefore, the purpose of this study was to build a unique database of patients with chronic hypoparathyroidism, derived from the databases of 16 referral centers for endocrinological diseases, affiliated with the Italian Society of Endocrinology, and four centers for endocrine surgery with expertise in hypoparathyroidism, to conduct an epidemiological analysis of chronic hypoparathyroidism in Italy. The study was approved by the Institutional Review Board. A total of 537 patients with chronic hypoparathyroidism were identified. The leading etiology was represented by postsurgical hypoparathyroidism (67.6%), followed by idiopathic hypoparathyroidism (14.6%), syndromic forms of genetic hypoparathyroidism (11%), forms of defective PTH action (5.2%), non-syndromic forms of genetic hypoparathyroidism (0.9%), and, finally, other forms of acquired hypoparathyroidism, due to infiltrative diseases, copper or iron overload, or ionizing radiation exposure (0.7%). This study represents one of the first large-scale epidemiological assessments of chronic hypoparathyroidism based on data collected at medical and/or surgical centers with expertise in hypoparathyroidism in Italy. Although the study presents some limitations, it introduces the possibility of a large-scale national survey, with the final aim of defining not only the prevalence of chronic hypoparathyroidism in Italy, but also standards for clinical and therapeutic approaches.
KW - Epidemiology
KW - Hypoparathyroidism
KW - Parathyroid hormone
KW - Therapy
KW - Thyroidectomy
UR - http://www.scopus.com/inward/record.url?scp=85048073675&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85048073675&partnerID=8YFLogxK
U2 - 10.1007/s00223-018-0411-7
DO - 10.1007/s00223-018-0411-7
M3 - Article
AN - SCOPUS:85048073675
VL - 103
SP - 151
EP - 163
JO - Calcified Tissue International
JF - Calcified Tissue International
SN - 0171-967X
IS - 2
ER -