HypoparaNet: A Database of Chronic Hypoparathyroidism Based on Expert Medical-Surgical Centers in Italy

Gemma Marcucci, Luisella Cianferotti, Simone Parri, Paola Altieri, Emanuela Arvat, Salvatore Benvenga, Corrado Betterle, Marta Bondanelli, Marco Boscaro, Valentina Camozzi, Grazia Maria Centaro, Filomena Cetani, Iacopo Chiodini, Anna Ciampolillo, Annamaria Colao, Sabrina Corbetta, Maria Laura De Feo, Ettore degli Uberti, Antongiulio Faggiano, Rachele FornariAchille Lucio Gaspari, Francesco Giorgino, Valeria Giuliani, Maurizio Iacobone, Nadia Innaro, Olga Lamacchia, Andrea Lenzi, Giovanna Mantovani, Claudio Marcocci, Laura Masi, Silvia Migliaccio, Serena Palmieri, Renato Pasquali, Giuliano Perigli, Valentina Piccini, Elisabetta Romagnoli, Rosaria Maddalena Ruggeri, Francesco Rulli, Maria Teresa Samà, Giuseppe Tomaino, Francesco Trimarchi, Maria Chiara Zatelli, Maria Luisa Brandi

Research output: Contribution to journalArticlepeer-review


Hypoparathyroidism is a rare disease characterized by low serum calcium levels and absent or deficient parathyroid hormone level. Regarding the epidemiology of chronic hypoparathyroidism, there are limited data in Italy and worldwide. Therefore, the purpose of this study was to build a unique database of patients with chronic hypoparathyroidism, derived from the databases of 16 referral centers for endocrinological diseases, affiliated with the Italian Society of Endocrinology, and four centers for endocrine surgery with expertise in hypoparathyroidism, to conduct an epidemiological analysis of chronic hypoparathyroidism in Italy. The study was approved by the Institutional Review Board. A total of 537 patients with chronic hypoparathyroidism were identified. The leading etiology was represented by postsurgical hypoparathyroidism (67.6%), followed by idiopathic hypoparathyroidism (14.6%), syndromic forms of genetic hypoparathyroidism (11%), forms of defective PTH action (5.2%), non-syndromic forms of genetic hypoparathyroidism (0.9%), and, finally, other forms of acquired hypoparathyroidism, due to infiltrative diseases, copper or iron overload, or ionizing radiation exposure (0.7%). This study represents one of the first large-scale epidemiological assessments of chronic hypoparathyroidism based on data collected at medical and/or surgical centers with expertise in hypoparathyroidism in Italy. Although the study presents some limitations, it introduces the possibility of a large-scale national survey, with the final aim of defining not only the prevalence of chronic hypoparathyroidism in Italy, but also standards for clinical and therapeutic approaches.

Original languageEnglish
Pages (from-to)151-163
JournalCalcified Tissue International
Issue number2
Publication statusPublished - 2018


  • Epidemiology
  • Hypoparathyroidism
  • Parathyroid hormone
  • Therapy
  • Thyroidectomy

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology


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