IPOFOSFATEMIA E DEPLEZIONE DI FOSFORO

STUDIO CLINICO IN CORSO DI INSUFFICIENZA RESPIRATORIA

Translated title of the contribution: Hypophosphatemia and phosphorus depletion: A clinical study in course of respiratory failure

E. Faiccadori, E. Coffrini, G. L. Gonzi, G. Tortorella, L. Bonandrini, C. Fracchia, T. Montagna, C. Rampulla, A. Borghetti

Research output: Contribution to journalArticle

Abstract

Twenty-two patients (19 M, 3 F, mean age 63 ± 6 SD) with respiratory failure (RF) due to chronic obstructive pulmonary disease (COPD), underwent peripheral muscle (quadriceps femoris) needle biopsy: in 14 of these patients, surgical biopsies of respiratory muscles (external intercostal muscles) were performed under local anesthesia. Muscle phosphorus content (P(m)) was measured in muscle fragments after acid digestion, by spectophotometric methods. Nutritional status (by anthropometric and biochemical indexes), as well as the main determinants of the overall phosphorus metabolism (dietary intake and renal phosphate handling indexes), were also evaluated. Thirty age- and sex-matched subjects were utilized as controls; P(m) of both respiratory and peripheral muscle of RF patients was reduced as compared to control subject values, irrespective of the reference index used for P(m) (fat-free dry-muscle weight, or muscle deoxyribonucleic acid content). A significant relationship between P(m) and serum phosphorus levels was demonstrated in the case of peripheral muscles only. No relationship was found between dietary phosphorus intake or nutritional status and P(m) of both types of skeletal muscles considered. Quadriceps femoris P(m) levels were directly related (though with a certain degree of scattering) to levels of renal phosphate threshold concentration, an index of the adequacy of renal compensatory mechanisms to hypophosphatemia and phosphorus depletion. Our study suggests that phosphorus depletion may be present in RF patients and that serum phosphorus levels are neither specific nor sensible indexes of phosphorus depletion in RF patients: phosphorus depletion, which occurs to a similar extent in skeletal muscles with different activity levels (respiratory and peripheral muscles) probably reflects the influence of systemic factors negatively affecting renal phosphate handling mechanisms involved in whole-body phosphorus homeostasis.

Original languageItalian
Pages (from-to)25-36
Number of pages12
JournalRivista Italiana di Nutrizione Parenterale ed Enterale
Volume10
Issue number1
Publication statusPublished - 1992

Fingerprint

Hypophosphatemia
Respiratory Insufficiency
Phosphorus
clinical trials
phosphorus
muscles
Muscles
Respiratory Muscles
Dietary Phosphorus
Kidney
kidneys
Phosphates
Quadriceps Muscle
Nutritional Status
phosphates
Skeletal Muscle
Intercostal Muscles
nutritional status
skeletal muscle
biopsy

ASJC Scopus subject areas

  • Food Science
  • Anatomy
  • Critical Care and Intensive Care Medicine
  • Nutrition and Dietetics

Cite this

Faiccadori, E., Coffrini, E., Gonzi, G. L., Tortorella, G., Bonandrini, L., Fracchia, C., ... Borghetti, A. (1992). IPOFOSFATEMIA E DEPLEZIONE DI FOSFORO: STUDIO CLINICO IN CORSO DI INSUFFICIENZA RESPIRATORIA. Rivista Italiana di Nutrizione Parenterale ed Enterale, 10(1), 25-36.

IPOFOSFATEMIA E DEPLEZIONE DI FOSFORO : STUDIO CLINICO IN CORSO DI INSUFFICIENZA RESPIRATORIA. / Faiccadori, E.; Coffrini, E.; Gonzi, G. L.; Tortorella, G.; Bonandrini, L.; Fracchia, C.; Montagna, T.; Rampulla, C.; Borghetti, A.

In: Rivista Italiana di Nutrizione Parenterale ed Enterale, Vol. 10, No. 1, 1992, p. 25-36.

Research output: Contribution to journalArticle

Faiccadori, E, Coffrini, E, Gonzi, GL, Tortorella, G, Bonandrini, L, Fracchia, C, Montagna, T, Rampulla, C & Borghetti, A 1992, 'IPOFOSFATEMIA E DEPLEZIONE DI FOSFORO: STUDIO CLINICO IN CORSO DI INSUFFICIENZA RESPIRATORIA', Rivista Italiana di Nutrizione Parenterale ed Enterale, vol. 10, no. 1, pp. 25-36.
Faiccadori E, Coffrini E, Gonzi GL, Tortorella G, Bonandrini L, Fracchia C et al. IPOFOSFATEMIA E DEPLEZIONE DI FOSFORO: STUDIO CLINICO IN CORSO DI INSUFFICIENZA RESPIRATORIA. Rivista Italiana di Nutrizione Parenterale ed Enterale. 1992;10(1):25-36.
Faiccadori, E. ; Coffrini, E. ; Gonzi, G. L. ; Tortorella, G. ; Bonandrini, L. ; Fracchia, C. ; Montagna, T. ; Rampulla, C. ; Borghetti, A. / IPOFOSFATEMIA E DEPLEZIONE DI FOSFORO : STUDIO CLINICO IN CORSO DI INSUFFICIENZA RESPIRATORIA. In: Rivista Italiana di Nutrizione Parenterale ed Enterale. 1992 ; Vol. 10, No. 1. pp. 25-36.
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