Hypopituitarism induced by traumatic brain injury in the transition phase

G. Aimaretti, M. R. Ambrosio, C. Di Somma, M. Gasperi, S. Cannavò, C. Scaroni, L. De Marinis, R. Baldelli, G. Bona, G. Giordano, E. Ghigo

Research output: Contribution to journalArticlepeer-review

Abstract

Traumatic brain injury (TBI) has been associated with hypopituitarism in general and GH deficiency (GHD) in particular; the consequences of this on growth and development are likely to be critical in children and adolescents in the so-called "transition phase". In order to verify the consequences of TBI on pituitary function in the transition phase, we studied a population of adolescents and young adults 3 and 12 months after brain injury [no.=23, 9 females, 14 males; age: 16-25 yr; body mass index (BMI): 21.9±0.6 kg/m 2]. At 3 months, hypopituitarism was present in 34.6%. Total, multiple and isolated deficits were present in 8.6, 4.3 and 21.7%, respectively. Diabetes insipidus (DI) was present in 8.6% patients and mild hyperprolactinemia in 4.3%. At 12 months, hypopituitarism was present in 30.3%. Total, multiple and isolated deficits were present in 8.6, 4.3 and 17.4%, respectively. D1 was present in 4.3% of patients and mild hyperprolactinemia in 4.3%. Total hypopituitarism was always confirmed at retesting. Multiple and isolated hypopituitarism were confirmed in 0/1 and 2/5, respectively. Two/23 patients showed isolated hypopituitarism at 12 months only; 1 patient with isolated at 3 months showed multiple hypopituitarism at retesting. GHD and secondary hypogonadism were the most common acquired pituitary deficits. These results show the high risk of TBI-induced hypopituitarism also in the transition age. Thus it is recommended that pediatric endocrinologists follow-up pituitary function of children and adolescents after brain injuries.

Original languageEnglish
Pages (from-to)984-989
Number of pages6
JournalJournal of Endocrinological Investigation
Volume28
Issue number11
Publication statusPublished - 2005

Keywords

  • Adolescence
  • Hypopituitarism
  • Transition phase
  • Traumatic brain injury

ASJC Scopus subject areas

  • Endocrinology

Fingerprint

Dive into the research topics of 'Hypopituitarism induced by traumatic brain injury in the transition phase'. Together they form a unique fingerprint.

Cite this