TY - JOUR
T1 - Hypotensive and renin suppressing activities of propranolol in hypertensive patients
AU - Leonetti, G.
AU - Mayer, G.
AU - Morganti, A.
AU - Terzoli, L.
AU - Zanchetti, A.
AU - Bianchetti, G.
AU - Di Salle, E.
AU - Morselli, P. L.
AU - Chidsey, C. A.
PY - 1975
Y1 - 1975
N2 - In patients with mild or moderate essential hypertension, oral propranolol, given in incremental doses, produced a moderate but significant lowering of blood pressure which was correlated with the concentration of propranolol in plasma. Propranolol also reduced plasma renin activity (PRA) in the supine posture, on standing and after i.v. frusemide. However, 'supine' and 'frusemide' PRA values were markedly reduced at a plasma concentration of propranolol that had little effect on blood pressure. On administration of propranolol there was little correlation between blood pressure decrease and PRA suppression, and even less between pretreatment PRA values and hypotensive response. It is concluded that in patients with mild and moderate hypertension and low or normal plasma renin activity, suppression of PRA is not an important determinant of the hypotensive response to propranolol.
AB - In patients with mild or moderate essential hypertension, oral propranolol, given in incremental doses, produced a moderate but significant lowering of blood pressure which was correlated with the concentration of propranolol in plasma. Propranolol also reduced plasma renin activity (PRA) in the supine posture, on standing and after i.v. frusemide. However, 'supine' and 'frusemide' PRA values were markedly reduced at a plasma concentration of propranolol that had little effect on blood pressure. On administration of propranolol there was little correlation between blood pressure decrease and PRA suppression, and even less between pretreatment PRA values and hypotensive response. It is concluded that in patients with mild and moderate hypertension and low or normal plasma renin activity, suppression of PRA is not an important determinant of the hypotensive response to propranolol.
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M3 - Article
C2 - 1056279
AN - SCOPUS:0016583456
VL - 48
SP - 491
EP - 499
JO - Clinical Science and Molecular Medicine
JF - Clinical Science and Molecular Medicine
SN - 0301-0538
IS - 6
ER -