L'amenorrea ipotalamica: Un esempio di disadattamento riproduttivo

Translated title of the contribution: Hypothalamic amenorrhea: An example of reproductive disadaptation

Rossella E. Nappi, Benedetta Brundu, Claudio Farina, Silvia Detaddei, Arianna Sommacal, Christian De Leonardis, Iolanda Chiapparini, Patrizia Vaccaro, Fabio Facchinetti, Franco Polatti

Research output: Contribution to journalArticlepeer-review


Functional hypothalamic amenorrhea is a common, non-organic and theoretically reversible form of anovulation due to reduced hypothalamic GnRH drive. Numerous studies suggest that this altered hypothalamic homeostasis is caused by a synergism between psychogenic challenge, promoted in part by dysfunctional attitudes, and metabolic compromise induced by undernutrition and overexercise. The recent growing interest in psychiatric comorbidity underlines the importance of reconsidering the boundaries between psychological disorders and somatic conditions. That not with standing, it is mandatory in gynecological endocrinology to explore the issue of secondary amenorrhea from a psychoneuroendocrine perspective in order to devise biopsychosocial interventions which address the individual distress. In this brief review we will try to critically discuss the issue providing evidences from personal studies as clues for better understanding the extent of the complex psychoneuroendocrine network controlling menstrual function.

Translated title of the contributionHypothalamic amenorrhea: An example of reproductive disadaptation
Original languageItalian
Pages (from-to)67-77
Number of pages11
JournalConfinia Cephalalgica
Issue number2
Publication statusPublished - 2002

ASJC Scopus subject areas

  • Clinical Neurology


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