Hypothalamic deep brain stimulation in positron emission tomography

Arne May, Massimo Leone, Henning Boecker, Till Sprenger, Tim Juergens, Gennaro Bussone, Thomas R. Tolle

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Recently, functional imaging data have underscored the crucial role the hypothalamus plays in cluster headache, one of the most severe forms of primary headache. This prompted the application of hypothalamic deep brain stimulation. Yet, it is not apparent how stimulation of an area that is thought to act as a pace-maker for acute headache attacks is able to prevent these attacks from occurring. We addressed this issue by examining 10 operated chronic cluster headache patients, using H2 15O-positron emission tomography and alternately switching the hypothalamic stimulator on and off. The stimulation induced activation in the ipsilateral hypothalamic gray (the site of the stimulator tip), the ipsilateral thalamus, somatosensory cortex and praecuneus, the anterior cingulate cortex, and the ipsilateral trigeminal nucleus and ganglion. We additionally observed deactivation in the middle temporal gyrus, posterior cingulate cortex, and contralateral anterior insula. Both activation and deactivation are situated in cerebral structures belonging to neuronal circuits usually activated in pain transmission and notably in acute cluster headache attacks. Our data argue against an unspecific antinociceptive effect or pure inhibition of hypothalamic activity. Instead, the data suggest a hitherto unrecognized functional modulation of the pain processing network as the mode of action of hypothalamic deep brain stimulation in cluster headache.

Original languageEnglish
Pages (from-to)3589-3593
Number of pages5
JournalJournal of Neuroscience
Volume26
Issue number13
DOIs
Publication statusPublished - Mar 29 2006

Fingerprint

Cluster Headache
Deep Brain Stimulation
Positron-Emission Tomography
Gyrus Cinguli
Headache
Trigeminal Nuclei
Pain
Trigeminal Ganglion
Parietal Lobe
Somatosensory Cortex
Temporal Lobe
Thalamus
Hypothalamus

Keywords

  • Cluster headache
  • Deep brain stimulation
  • Hypothalamus
  • Neuromodulation
  • PET, pain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

May, A., Leone, M., Boecker, H., Sprenger, T., Juergens, T., Bussone, G., & Tolle, T. R. (2006). Hypothalamic deep brain stimulation in positron emission tomography. Journal of Neuroscience, 26(13), 3589-3593. https://doi.org/10.1523/JNEUROSCI.4609-05.2006

Hypothalamic deep brain stimulation in positron emission tomography. / May, Arne; Leone, Massimo; Boecker, Henning; Sprenger, Till; Juergens, Tim; Bussone, Gennaro; Tolle, Thomas R.

In: Journal of Neuroscience, Vol. 26, No. 13, 29.03.2006, p. 3589-3593.

Research output: Contribution to journalArticle

May, A, Leone, M, Boecker, H, Sprenger, T, Juergens, T, Bussone, G & Tolle, TR 2006, 'Hypothalamic deep brain stimulation in positron emission tomography', Journal of Neuroscience, vol. 26, no. 13, pp. 3589-3593. https://doi.org/10.1523/JNEUROSCI.4609-05.2006
May, Arne ; Leone, Massimo ; Boecker, Henning ; Sprenger, Till ; Juergens, Tim ; Bussone, Gennaro ; Tolle, Thomas R. / Hypothalamic deep brain stimulation in positron emission tomography. In: Journal of Neuroscience. 2006 ; Vol. 26, No. 13. pp. 3589-3593.
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