Hypothalamic serotonergic activity correlates better with brain temperature than with sleep-wake cycle and muscle tone in rats

L. Imeri, C. Gemma, M. G. De Simoni, M. R. Opp, M. Mancia

Research output: Contribution to journalArticlepeer-review

Abstract

The activity of the serotonergic system varies in phase with the sleep- wake cycle, which is associated with changes in several physiological functions, including electroencephalographic activity, brain temperature, and locomotion. The aim of the present study was to clarify which of these parameters correlates better with serotonergic activity in spontaneous conditions. Voltammetric recordings by telemetry of serotonergic metabolism in the medial preoptic area and polygraphic recordings of sleep-wake activity (by means of electroencephalographic delta band, brain cortical temperature and neck electromyographic activity recordings) were simultaneously performed in freely moving rats. Univariate analyses of variance revealed that each variable under investigation was statistically correlated with serotonergic metabolism. When the variables were entered into the model simultaneously, both partial correlation and step-wise multiple regression analyses indicated that the highest correlation exists between serotonergic metabolism and brain cortical temperature. The present data show that serotonergic activity in the medial preoptic area is closely linked to physiological changes in brain temperature.

Original languageEnglish
Pages (from-to)1241-1246
Number of pages6
JournalNeuroscience
Volume89
Issue number4
DOIs
Publication statusPublished - 1999

Keywords

  • In vivo voltammetry
  • Locomotion
  • Medial preoptic area
  • Serotonin
  • Telemetry
  • Thermoregulation

ASJC Scopus subject areas

  • Neuroscience(all)

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