Hypothalamus-pituitary-adrenal axis in central diabetes insipidus: ACTH and cortisol responsiveness to CRH administration

R. Pivonello, A. Faggiano, M. Filippella, C. Di Somma, M. C. De Martino, M. Gaccione, G. Lombardi, Annamaria Colao

Research output: Contribution to journalArticlepeer-review


A strong relationship has been found between arginine-vasopressin (AVP) and hypothalamus-pituitary-adrenal axis in humans. The aim of the current study was to evaluate baseline and CRH-stimulated ACTH and F levels in patients with central diabetes insipidus (CDI), before and after replacement therapy with desamino-D-AVP (DDAVP). Twenty-five patients with CDI, and 25 sex- and age- and BMI-matched healthy subjects entered the study. A standard CRH test (measurement of plasma ACTH and serum F before and every 15 min for 2 h after the administration of 100 μg of human CRH) was performed in all subjects. In patients with CDI, CRH test were repeated after 1 week of DDAVP at standard doses. At study entry, ACTH and F levels were significantly higher in patients with CDI than in controls either at baseline (ACTH: 45.5±4.8 vs 18.5±3.3 ng/l, p

Original languageEnglish
Pages (from-to)932-937
Number of pages6
JournalJournal of Endocrinological Investigation
Issue number11
Publication statusPublished - Dec 2002


  • Adrenal
  • Arginine vasopressin
  • Corticotropin
  • Corticotropin-releasing hormone
  • Diabetes insipidus
  • Glucocorticoids
  • Pituitary

ASJC Scopus subject areas

  • Endocrinology


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