Hypothesis: The 'metabolic memory', the new challenge of diabetes

M. A. Ihnat, J. E. Thorpe, A. Ceriello

Research output: Contribution to journalArticle

Abstract

Large randomized studies have established that early intensive glycaemic control reduces the risk of diabetic complications, both micro- and macrovascular. However, epidemiological and prospective data support a long-term influence of early metabolic control on clinical outcomes. This phenomenon has recently been defined as 'metabolic memory.' Potential mechanisms for propagating this 'memory' are the non-enzymatic glycation of cellular proteins and lipids, and an excess of cellular reactive oxygen and nitrogen species, in particular originated at the level of glycated-mitochondrial proteins, perhaps acting in concert with one another to maintain stress signalling. Furthermore, the emergence of this 'metabolic memory' suggests the need for very early aggressive treatment aiming to 'normalize' glycaemic control and the addition of agents which reduce cellular reactive species and glycation in order to minimize long-term diabetic complications.

Original languageEnglish
Pages (from-to)582-586
Number of pages5
JournalDiabetic Medicine
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2007

    Fingerprint

Keywords

  • Diabetic complications
  • Metabolic memory
  • Mitochondria
  • Non-enzymatic glycation
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology
  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this