Hypoxia and Amino Acid Imaging of High-Grade Glioma: 18F-FAZA PET/CT and 11C-Methionine PET/MRI

Paola Mapelli, Federico Fallanca, Paola Scifo, Maurizio Barbera, Antonella Castellano, Valentino Bettinardi, Elena Incerti, Luigi Gianolli, Nicoletta Anzalone, Maria Picchio

Research output: Contribution to journalArticlepeer-review

Abstract

In the present case, we report the first experience of a patient with high-grade glioma who underwent dual 18F-FAZA PET/CT imaging for intratumoral hypoxia assessment, before treatment, and for therapy monitoring in the suspicious of recurrence, as part of a clinical research protocol. In addition, despite the diagnosis of glioblastoma, the patient at 3 years from diagnosis was alive and underwent 11C-methionine simultaneous PET/MRI for disease monitoring after treatment, showing stability of disease. The multitracer capability of PET in assessing different and complementary metabolic features along with the use of a last-generation scanner as PET/MRI in brain oncology are here enlighten.

Original languageEnglish
Pages (from-to)e290-e293
JournalClinical Nuclear Medicine
Volume45
Issue number6
DOIs
Publication statusPublished - Jun 1 2020

Keywords

  • C-Methionine
  • F-FAZA
  • glioma
  • PET/CT
  • PET/MRI

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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