Hypoxia inhibits the expression of the CCR5 chemokine receptor in macrophages

Maria Carla Bosco, Gioia Reffo, Maura Puppo, Luigi Varesio

Research output: Contribution to journalArticlepeer-review


Hypoxia, a decrease in oxygen tension occurring in pathological tissues, has a profound effect on macrophage functions. Here, we provide the first evidence that hypoxia inhibits CCR5 chemokine receptor expression in mouse macrophages. CCR5 was constitutively expressed in macrophages and upregulated by IFNγ. Hypoxia downregulated both constitutive and IFNγ-induced CCR5 mRNA and protein. Reoxygenation of hypoxic cells reverted CCR5 inhibition. CCR5 upregulation by IL-10, LPS, and IL-4 was also antagonized by hypoxia. CCR5 inhibition may be a way to retain/concentrate recruited macrophages at hypoxic sites or a feedback mechanism to control the autocrine activation of macrophages which produce CCR5 ligands.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalCellular Immunology
Issue number1
Publication statusPublished - Mar 2004


  • CCR5
  • Chemokine receptors
  • Gene expression
  • Hypoxia
  • Inflammatory signals
  • Macrophages

ASJC Scopus subject areas

  • Cell Biology
  • Immunology


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