Hypoxia response and microRNAs: No longer two separate worlds

Mircea Ivan, Adrian L. Harris, Fabio Martelli, Ritu Kulshreshtha

Research output: Contribution to journalArticle

Abstract

MicroRNAs (miRs) are short non-coding transcripts involved in a wide variety of cellular processes. Several recent studies have established a link between hypoxia, a well-documented component of the tumour microenvironment, and specific miRs. One member of this class, miR-210, was identified as hypoxia inducible in all the cell types tested, and is overexpressed in most cancer types. Its hypoxic induction is dependent on a functional hypoxia-inducible factor (HIF), thus extending the transcriptional repertoire of the latter beyond 'classic' genes. From a clinical standpoint, miR-210 overexpression has been associated with adverse prognosis in breast tumours and been detected in serum of lymphoma patients and could serve as a tool to define hypoxic malignancies. We discuss the role of miR-210 and its emerging targets, as well as possible future directions for clinical applications in oncology and ischaemic disorders.

Original languageEnglish
Pages (from-to)1426-1431
Number of pages6
JournalJournal of Cellular and Molecular Medicine
Volume12
Issue number5A
DOIs
Publication statusPublished - Sep 2008

Keywords

  • Cancer
  • HIF
  • Hypoxia
  • Ischemia
  • MicroRNAs
  • miR-210

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine

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