TY - JOUR
T1 - Hypoxia response and microRNAs
T2 - No longer two separate worlds
AU - Ivan, Mircea
AU - Harris, Adrian L.
AU - Martelli, Fabio
AU - Kulshreshtha, Ritu
PY - 2008/9
Y1 - 2008/9
N2 - MicroRNAs (miRs) are short non-coding transcripts involved in a wide variety of cellular processes. Several recent studies have established a link between hypoxia, a well-documented component of the tumour microenvironment, and specific miRs. One member of this class, miR-210, was identified as hypoxia inducible in all the cell types tested, and is overexpressed in most cancer types. Its hypoxic induction is dependent on a functional hypoxia-inducible factor (HIF), thus extending the transcriptional repertoire of the latter beyond 'classic' genes. From a clinical standpoint, miR-210 overexpression has been associated with adverse prognosis in breast tumours and been detected in serum of lymphoma patients and could serve as a tool to define hypoxic malignancies. We discuss the role of miR-210 and its emerging targets, as well as possible future directions for clinical applications in oncology and ischaemic disorders.
AB - MicroRNAs (miRs) are short non-coding transcripts involved in a wide variety of cellular processes. Several recent studies have established a link between hypoxia, a well-documented component of the tumour microenvironment, and specific miRs. One member of this class, miR-210, was identified as hypoxia inducible in all the cell types tested, and is overexpressed in most cancer types. Its hypoxic induction is dependent on a functional hypoxia-inducible factor (HIF), thus extending the transcriptional repertoire of the latter beyond 'classic' genes. From a clinical standpoint, miR-210 overexpression has been associated with adverse prognosis in breast tumours and been detected in serum of lymphoma patients and could serve as a tool to define hypoxic malignancies. We discuss the role of miR-210 and its emerging targets, as well as possible future directions for clinical applications in oncology and ischaemic disorders.
KW - Cancer
KW - HIF
KW - Hypoxia
KW - Ischemia
KW - MicroRNAs
KW - miR-210
UR - http://www.scopus.com/inward/record.url?scp=54049105673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=54049105673&partnerID=8YFLogxK
U2 - 10.1111/j.1582-4934.2008.00398.x
DO - 10.1111/j.1582-4934.2008.00398.x
M3 - Article
C2 - 18624759
AN - SCOPUS:54049105673
VL - 12
SP - 1426
EP - 1431
JO - Journal of Cellular and Molecular Medicine
JF - Journal of Cellular and Molecular Medicine
SN - 1582-1838
IS - 5A
ER -