Hypoxic isolated limb perfusion with mitomycin C in locally recurrent melanoma and sarcoma: Results of a phase II study

G. Fiorentini, D. Poddie, G. Graziani, S. Ricci, C. Baccini, G. Rossi, M. Leoni, C. Dazzi, R. Roversi

Research output: Contribution to journalArticle

Abstract

Conventional isolated limb perfusion is of proven efficacy in treatment of recurrent sarcomas and melanomas confined to a limb. However the techniques previously described require highly specialized staff and facilities. In this study a more simple technique was used taking advantage of the increased activity of Mitomycin C under hypoxic conditions. 9 patients were treated, 7 with tumour recurrences in a limb and 2 after resection of melanoma recurrences in a limb. One of two simplified treatment techniques was used. These were a radiological approach using 8 FG catheters or a surgical approach using 14 FG catheters. After tourniquet limb isolation heparin and a calculated dose of Mitomycin C in saline was infused into the limb artery and the circulation was perfused using an extra corporeal pump. After 20-40 minutes circulation limb fluid containing the Mitomycin was exchanged for a saline/albumin solution. Tourniquets were removed and the body circulation restored. Results achieved in the 7 patients with recurrent tumours were 1 CR (the one patient with angiosarcoma); 4 PR (2 sarcomas and 2 melanomas); 1 SD (chondrosarcoma) and 1 PD (osteosarcoma). The 2 patients treated after recurrent melanoma resection remain well to date (5 months and 6 months). The techniques used take advantage of the increased activity of Mitomycin C under hypoxic conditions and without need for hypothermia. The techniques are simple, effective and relatively non toxic. They could be safely used in many general hospitals.

Original languageEnglish
Pages (from-to)135-139
Number of pages5
JournalRegional Cancer Treatment
Volume8
Issue number3-4
Publication statusPublished - 1995

Keywords

  • Hypoxia
  • Hypoxic isolated limb perfusion
  • Limb melanoma
  • Limb sarcoma
  • Mitomycin C

ASJC Scopus subject areas

  • Oncology
  • Pharmacology

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    Fiorentini, G., Poddie, D., Graziani, G., Ricci, S., Baccini, C., Rossi, G., Leoni, M., Dazzi, C., & Roversi, R. (1995). Hypoxic isolated limb perfusion with mitomycin C in locally recurrent melanoma and sarcoma: Results of a phase II study. Regional Cancer Treatment, 8(3-4), 135-139.