Hysterectomy with or without unilateral oophorectomy and risk of ovarian cancer

Francesca Chiaffarino, Fabio Parazzini, Adriano Decarli, Silvia Franceschi, Renato Talamini, Maurizio Montella, Carlo La Vecchia

Research output: Contribution to journalArticle

Abstract

Objective. To analyze the role of hysterectomy, performed on benign indications, on the risk of developing ovarian cancer. Methods. Multicenter case-control study conducted in four Italian areas. Cases were 1031 women with epithelial ovarian cancer. Controls were 2411 women admitted to the same network of hospitals for a wide spectrum of acute non-neoplastic conditions, unrelated to known risk factors for ovarian cancer. Results. Compared to women with intact uterus and ovaries, the multivariate odds ratios (OR) was 0.6 (95% confidence interval 0.4-0.9) for women who reported hysterectomy. The OR was 0.5 ≥15 years after surgery. The OR was similar for women who had had pelvic surgery before age 45 and for those who had surgery later. No appreciable heterogeneity emerged across strata of parity and family history of ovarian/breast cancer. Conclusion. Women who had undergone hysterectomy had a long-term reduced risk of epithelial ovarian cancer.

Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalGynecologic Oncology
Volume97
Issue number2
DOIs
Publication statusPublished - May 2005

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Ovariectomy
Hysterectomy
Ovarian Neoplasms
Odds Ratio
Parity
Uterus
Case-Control Studies
Ovary
Confidence Intervals
Breast Neoplasms

Keywords

  • Hysterectomy
  • Ovarian cancer
  • Risk factor

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Hysterectomy with or without unilateral oophorectomy and risk of ovarian cancer. / Chiaffarino, Francesca; Parazzini, Fabio; Decarli, Adriano; Franceschi, Silvia; Talamini, Renato; Montella, Maurizio; La Vecchia, Carlo.

In: Gynecologic Oncology, Vol. 97, No. 2, 05.2005, p. 318-322.

Research output: Contribution to journalArticle

Chiaffarino, Francesca ; Parazzini, Fabio ; Decarli, Adriano ; Franceschi, Silvia ; Talamini, Renato ; Montella, Maurizio ; La Vecchia, Carlo. / Hysterectomy with or without unilateral oophorectomy and risk of ovarian cancer. In: Gynecologic Oncology. 2005 ; Vol. 97, No. 2. pp. 318-322.
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AU - Montella, Maurizio

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