Hysterectomy with or without unilateral oophorectomy and risk of ovarian cancer

Francesca Chiaffarino, Fabio Parazzini, Adriano Decarli, Silvia Franceschi, Renato Talamini, Maurizio Montella, Carlo La Vecchia

Research output: Contribution to journalArticle


Objective. To analyze the role of hysterectomy, performed on benign indications, on the risk of developing ovarian cancer. Methods. Multicenter case-control study conducted in four Italian areas. Cases were 1031 women with epithelial ovarian cancer. Controls were 2411 women admitted to the same network of hospitals for a wide spectrum of acute non-neoplastic conditions, unrelated to known risk factors for ovarian cancer. Results. Compared to women with intact uterus and ovaries, the multivariate odds ratios (OR) was 0.6 (95% confidence interval 0.4-0.9) for women who reported hysterectomy. The OR was 0.5 ≥15 years after surgery. The OR was similar for women who had had pelvic surgery before age 45 and for those who had surgery later. No appreciable heterogeneity emerged across strata of parity and family history of ovarian/breast cancer. Conclusion. Women who had undergone hysterectomy had a long-term reduced risk of epithelial ovarian cancer.

Original languageEnglish
Pages (from-to)318-322
Number of pages5
JournalGynecologic Oncology
Issue number2
Publication statusPublished - May 2005


  • Hysterectomy
  • Ovarian cancer
  • Risk factor

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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