IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71)

G. F. Bottazzo; E. Bosi; C. A. Cull; E. Bonifacio; M. Locatelli; P. Zimmet; I. R. MacKay; R. R. Holman

doi:10.1007/s00125-005-1691-9

IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71)

G. F. Bottazzo, E. Bosi, C. A. Cull, E. Bonifacio, M. Locatelli, P. Zimmet, I. R. MacKay, R. R. Holman

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Aims/hypothesis: Established autoimmune markers of type 1 diabetes, including islet cell autoantibodies (ICA) and autoantibodies to glutamic acid decarboxylase (GADA) have been used to screen people presenting with type 2 diabetes for latent autoimmune diabetes in adults. We have examined the prevalence of autoantibodies to protein tyrosine phosphatase isoforms IA-2 (IA-2A) and IA-2β/phogrin (IA-2βA) in a cohort of adult UKPDS patients thought to have type 2 diabetes, and investigated the possible role of these autoantibodies in predicting requirement for insulin therapy. Methods: IA-2A and IA-2βA were measured by a validated radioimmunoassay with human recombinant autoantigens in 4,169 white Caucasian patients aged 25-65 years and newly diagnosed with type 2 diabetes. The clinical requirement for insulin therapy within 6 years was examined in 2,556 patients not randomised to insulin. Results: IA-2A and IA-2βA were present in 2.2 and 1.4%, respectively, of these patients. IA-2A were more prevalent in younger patients (p for trend

Original language	English
Pages (from-to)	703-708
Number of pages	6
Journal	Diabetologia
Volume	48
Issue number	4
DOIs	https://doi.org/10.1007/s00125-005-1691-9
Publication status	Published - Apr 2005

Keywords

GADA
IA2A
ICA
Insulin requirement
Islet cell autoantibodies
Type 2 diabetes
UKPDS

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism

Access to Document

10.1007/s00125-005-1691-9

Cite this

@article{93e69e7993264de7b333e83bba148bd8,

title = "IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71)",

abstract = "Aims/hypothesis: Established autoimmune markers of type 1 diabetes, including islet cell autoantibodies (ICA) and autoantibodies to glutamic acid decarboxylase (GADA) have been used to screen people presenting with type 2 diabetes for latent autoimmune diabetes in adults. We have examined the prevalence of autoantibodies to protein tyrosine phosphatase isoforms IA-2 (IA-2A) and IA-2β/phogrin (IA-2βA) in a cohort of adult UKPDS patients thought to have type 2 diabetes, and investigated the possible role of these autoantibodies in predicting requirement for insulin therapy. Methods: IA-2A and IA-2βA were measured by a validated radioimmunoassay with human recombinant autoantigens in 4,169 white Caucasian patients aged 25-65 years and newly diagnosed with type 2 diabetes. The clinical requirement for insulin therapy within 6 years was examined in 2,556 patients not randomised to insulin. Results: IA-2A and IA-2βA were present in 2.2 and 1.4%, respectively, of these patients. IA-2A were more prevalent in younger patients (p for trend ",

keywords = "GADA, IA2A, ICA, Insulin requirement, Islet cell autoantibodies, Type 2 diabetes, UKPDS",

author = "Bottazzo, {G. F.} and E. Bosi and Cull, {C. A.} and E. Bonifacio and M. Locatelli and P. Zimmet and MacKay, {I. R.} and Holman, {R. R.}",

year = "2005",

month = apr,

doi = "10.1007/s00125-005-1691-9",

language = "English",

volume = "48",

pages = "703--708",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer Verlag",

number = "4",

}

TY - JOUR

T1 - IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71)

AU - Bottazzo, G. F.

AU - Bosi, E.

AU - Cull, C. A.

AU - Bonifacio, E.

AU - Locatelli, M.

AU - Zimmet, P.

AU - MacKay, I. R.

AU - Holman, R. R.

PY - 2005/4

Y1 - 2005/4

N2 - Aims/hypothesis: Established autoimmune markers of type 1 diabetes, including islet cell autoantibodies (ICA) and autoantibodies to glutamic acid decarboxylase (GADA) have been used to screen people presenting with type 2 diabetes for latent autoimmune diabetes in adults. We have examined the prevalence of autoantibodies to protein tyrosine phosphatase isoforms IA-2 (IA-2A) and IA-2β/phogrin (IA-2βA) in a cohort of adult UKPDS patients thought to have type 2 diabetes, and investigated the possible role of these autoantibodies in predicting requirement for insulin therapy. Methods: IA-2A and IA-2βA were measured by a validated radioimmunoassay with human recombinant autoantigens in 4,169 white Caucasian patients aged 25-65 years and newly diagnosed with type 2 diabetes. The clinical requirement for insulin therapy within 6 years was examined in 2,556 patients not randomised to insulin. Results: IA-2A and IA-2βA were present in 2.2 and 1.4%, respectively, of these patients. IA-2A were more prevalent in younger patients (p for trend

AB - Aims/hypothesis: Established autoimmune markers of type 1 diabetes, including islet cell autoantibodies (ICA) and autoantibodies to glutamic acid decarboxylase (GADA) have been used to screen people presenting with type 2 diabetes for latent autoimmune diabetes in adults. We have examined the prevalence of autoantibodies to protein tyrosine phosphatase isoforms IA-2 (IA-2A) and IA-2β/phogrin (IA-2βA) in a cohort of adult UKPDS patients thought to have type 2 diabetes, and investigated the possible role of these autoantibodies in predicting requirement for insulin therapy. Methods: IA-2A and IA-2βA were measured by a validated radioimmunoassay with human recombinant autoantigens in 4,169 white Caucasian patients aged 25-65 years and newly diagnosed with type 2 diabetes. The clinical requirement for insulin therapy within 6 years was examined in 2,556 patients not randomised to insulin. Results: IA-2A and IA-2βA were present in 2.2 and 1.4%, respectively, of these patients. IA-2A were more prevalent in younger patients (p for trend

KW - GADA

KW - IA2A

KW - ICA

KW - Insulin requirement

KW - Islet cell autoantibodies

KW - Type 2 diabetes

KW - UKPDS

UR - http://www.scopus.com/inward/record.url?scp=17844403542&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=17844403542&partnerID=8YFLogxK

U2 - 10.1007/s00125-005-1691-9

DO - 10.1007/s00125-005-1691-9

M3 - Article

C2 - 15765222

AN - SCOPUS:17844403542

VL - 48

SP - 703

EP - 708

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 4

ER -

IA-2 antibody prevalence and risk assessment of early insulin requirement in subjects presenting with type 2 diabetes (UKPDS 71)

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this