ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution

Luca Castelli, Cristoforo Comi, Annalisa Chiocchetti, Stefania Nicola, Riccardo Mesturini, Mara Giordano, Sandra D'Alfonso, Elisa Cerutti, Daniela Galimberti, Chiara Fenoglio, Fabiana Tesser, Junji Yagi, José Maria Rojo, Franco Perla, Maurizio Leone, Elio Scarpini, Francesco Monaco, Umberto Dianzani

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Human ICOS is a T cell costimulatory molecule supporting IL10 secretion. A pilot study investigating variations of the ICOS gene 3'UTR detected 8 polymorphisms forming three haplotypes (A, B, C). Haplotype-A and -C displayed the highest difference. Activated T cells from healthy AA homozygotes expressed significantly less ICOS and secreted more IL10 than AC heterozygotes, whereas AB heterozygotes displayed intermediate levels. Analysis of 441 multiple sclerosis patients and 793 controls showed that frequency of AA homozygosity was significantly lower in MS patients with relapsing-remitting onset (N = 416) than in controls (OR = 0.70). Moreover, AA patients with relapsing-remitting onset had lower relapse rate and multiple sclerosis severity score than non-AA patients.

Original languageEnglish
Pages (from-to)193-198
Number of pages6
JournalJournal of Neuroimmunology
Volume186
Issue number1-2
DOIs
Publication statusPublished - May 2007

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Interleukin-10
Haplotypes
Multiple Sclerosis
Heterozygote
Genes
T-Lymphocytes
Homozygote
3' Untranslated Regions
Recurrence

Keywords

  • ICOS
  • IL10
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Castelli, L., Comi, C., Chiocchetti, A., Nicola, S., Mesturini, R., Giordano, M., ... Dianzani, U. (2007). ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution. Journal of Neuroimmunology, 186(1-2), 193-198. https://doi.org/10.1016/j.jneuroim.2007.03.022

ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution. / Castelli, Luca; Comi, Cristoforo; Chiocchetti, Annalisa; Nicola, Stefania; Mesturini, Riccardo; Giordano, Mara; D'Alfonso, Sandra; Cerutti, Elisa; Galimberti, Daniela; Fenoglio, Chiara; Tesser, Fabiana; Yagi, Junji; Rojo, José Maria; Perla, Franco; Leone, Maurizio; Scarpini, Elio; Monaco, Francesco; Dianzani, Umberto.

In: Journal of Neuroimmunology, Vol. 186, No. 1-2, 05.2007, p. 193-198.

Research output: Contribution to journalArticle

Castelli, L, Comi, C, Chiocchetti, A, Nicola, S, Mesturini, R, Giordano, M, D'Alfonso, S, Cerutti, E, Galimberti, D, Fenoglio, C, Tesser, F, Yagi, J, Rojo, JM, Perla, F, Leone, M, Scarpini, E, Monaco, F & Dianzani, U 2007, 'ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution', Journal of Neuroimmunology, vol. 186, no. 1-2, pp. 193-198. https://doi.org/10.1016/j.jneuroim.2007.03.022
Castelli L, Comi C, Chiocchetti A, Nicola S, Mesturini R, Giordano M et al. ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution. Journal of Neuroimmunology. 2007 May;186(1-2):193-198. https://doi.org/10.1016/j.jneuroim.2007.03.022
Castelli, Luca ; Comi, Cristoforo ; Chiocchetti, Annalisa ; Nicola, Stefania ; Mesturini, Riccardo ; Giordano, Mara ; D'Alfonso, Sandra ; Cerutti, Elisa ; Galimberti, Daniela ; Fenoglio, Chiara ; Tesser, Fabiana ; Yagi, Junji ; Rojo, José Maria ; Perla, Franco ; Leone, Maurizio ; Scarpini, Elio ; Monaco, Francesco ; Dianzani, Umberto. / ICOS gene haplotypes correlate with IL10 secretion and multiple sclerosis evolution. In: Journal of Neuroimmunology. 2007 ; Vol. 186, No. 1-2. pp. 193-198.
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