ICSI outcome is significantly better with testicular spermatozoa in patients with necrozoospermia: A retrospective study

Luciano Negri, Pasquale Patrizio, Elena Albani, Emanuela Morenghi, Renzo Benaglia, Marcello Desgro, Paolo Emanuele Levi Setti

Research output: Contribution to journalArticle

Abstract

Objective: To determine whether intracytoplasmic sperm injection (ICSI) outcome with testicular sperm is superior to that of ejaculated sperm in men with incomplete necrozoospermia, defined as sperm viability ≥5 to ≤45%. Study design: Retrospective study at a Reproductive Medicine Center of a tertiary referral hospital. A total of 231 couples with male infertility due to incomplete necrozoospermia underwent 342 ICSI cycles with freshly ejaculated sperm (ICSI-ejaculated) and 182 cycles with testicular sperm (ICSI-TESE). Results: Overall 1624 MII oocytes were injected in the ICSI-ejaculated group with a fertilisation rate of 60.8%, while in ICSI- TESE cycles the fertilisation rate was 59.6% in 874 MII oocytes. The cleavage rate was higher in ICSI-ejaculated cycles than in ICSI-TESE cycles (96.3% versus 92.9%; p = 0.004). However, the pregnancy and implantation rates per cycle were significantly higher in the ICSI-TESE group (67/182, 36.8% versus 68/342, 19.9% (p = 0.0001); and 23.7% versus 12.7% (p = 0.0001), respectively). The miscarriage rate was similar (ICSI-ejaculated 26.5% versus ICSI-TESE 17.9%, p = 0.301). Live birth rate per cycle in the ICSI-ejaculated group was significantly lower than in the ICSI-TESE (13.7% versus 28.6%, p = 0.0001). Conclusions: In cases of persistent necrozoospermia, testicular sperm should be favoured over ejaculated sperm. These data call for more research to understand the pathophysiology of refractory necrozoospermia.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalGynecological Endocrinology
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 2014

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Intracytoplasmic Sperm Injections
Spermatozoa
Retrospective Studies
Fertilization
Oocytes
Reproductive Medicine
Birth Rate
Male Infertility
Live Birth
Spontaneous Abortion
Pregnancy Rate
Tertiary Care Centers

Keywords

  • Intracytoplasmic sperm injection (ICSI)
  • Male infertility
  • Necrozoospermia
  • Testicular sperm extraction (TESE)

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Obstetrics and Gynaecology

Cite this

ICSI outcome is significantly better with testicular spermatozoa in patients with necrozoospermia : A retrospective study. / Negri, Luciano; Patrizio, Pasquale; Albani, Elena; Morenghi, Emanuela; Benaglia, Renzo; Desgro, Marcello; Levi Setti, Paolo Emanuele.

In: Gynecological Endocrinology, Vol. 30, No. 1, 01.2014, p. 48-52.

Research output: Contribution to journalArticle

Negri, Luciano ; Patrizio, Pasquale ; Albani, Elena ; Morenghi, Emanuela ; Benaglia, Renzo ; Desgro, Marcello ; Levi Setti, Paolo Emanuele. / ICSI outcome is significantly better with testicular spermatozoa in patients with necrozoospermia : A retrospective study. In: Gynecological Endocrinology. 2014 ; Vol. 30, No. 1. pp. 48-52.
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title = "ICSI outcome is significantly better with testicular spermatozoa in patients with necrozoospermia: A retrospective study",
abstract = "Objective: To determine whether intracytoplasmic sperm injection (ICSI) outcome with testicular sperm is superior to that of ejaculated sperm in men with incomplete necrozoospermia, defined as sperm viability ≥5 to ≤45{\%}. Study design: Retrospective study at a Reproductive Medicine Center of a tertiary referral hospital. A total of 231 couples with male infertility due to incomplete necrozoospermia underwent 342 ICSI cycles with freshly ejaculated sperm (ICSI-ejaculated) and 182 cycles with testicular sperm (ICSI-TESE). Results: Overall 1624 MII oocytes were injected in the ICSI-ejaculated group with a fertilisation rate of 60.8{\%}, while in ICSI- TESE cycles the fertilisation rate was 59.6{\%} in 874 MII oocytes. The cleavage rate was higher in ICSI-ejaculated cycles than in ICSI-TESE cycles (96.3{\%} versus 92.9{\%}; p = 0.004). However, the pregnancy and implantation rates per cycle were significantly higher in the ICSI-TESE group (67/182, 36.8{\%} versus 68/342, 19.9{\%} (p = 0.0001); and 23.7{\%} versus 12.7{\%} (p = 0.0001), respectively). The miscarriage rate was similar (ICSI-ejaculated 26.5{\%} versus ICSI-TESE 17.9{\%}, p = 0.301). Live birth rate per cycle in the ICSI-ejaculated group was significantly lower than in the ICSI-TESE (13.7{\%} versus 28.6{\%}, p = 0.0001). Conclusions: In cases of persistent necrozoospermia, testicular sperm should be favoured over ejaculated sperm. These data call for more research to understand the pathophysiology of refractory necrozoospermia.",
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T1 - ICSI outcome is significantly better with testicular spermatozoa in patients with necrozoospermia

T2 - A retrospective study

AU - Negri, Luciano

AU - Patrizio, Pasquale

AU - Albani, Elena

AU - Morenghi, Emanuela

AU - Benaglia, Renzo

AU - Desgro, Marcello

AU - Levi Setti, Paolo Emanuele

PY - 2014/1

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N2 - Objective: To determine whether intracytoplasmic sperm injection (ICSI) outcome with testicular sperm is superior to that of ejaculated sperm in men with incomplete necrozoospermia, defined as sperm viability ≥5 to ≤45%. Study design: Retrospective study at a Reproductive Medicine Center of a tertiary referral hospital. A total of 231 couples with male infertility due to incomplete necrozoospermia underwent 342 ICSI cycles with freshly ejaculated sperm (ICSI-ejaculated) and 182 cycles with testicular sperm (ICSI-TESE). Results: Overall 1624 MII oocytes were injected in the ICSI-ejaculated group with a fertilisation rate of 60.8%, while in ICSI- TESE cycles the fertilisation rate was 59.6% in 874 MII oocytes. The cleavage rate was higher in ICSI-ejaculated cycles than in ICSI-TESE cycles (96.3% versus 92.9%; p = 0.004). However, the pregnancy and implantation rates per cycle were significantly higher in the ICSI-TESE group (67/182, 36.8% versus 68/342, 19.9% (p = 0.0001); and 23.7% versus 12.7% (p = 0.0001), respectively). The miscarriage rate was similar (ICSI-ejaculated 26.5% versus ICSI-TESE 17.9%, p = 0.301). Live birth rate per cycle in the ICSI-ejaculated group was significantly lower than in the ICSI-TESE (13.7% versus 28.6%, p = 0.0001). Conclusions: In cases of persistent necrozoospermia, testicular sperm should be favoured over ejaculated sperm. These data call for more research to understand the pathophysiology of refractory necrozoospermia.

AB - Objective: To determine whether intracytoplasmic sperm injection (ICSI) outcome with testicular sperm is superior to that of ejaculated sperm in men with incomplete necrozoospermia, defined as sperm viability ≥5 to ≤45%. Study design: Retrospective study at a Reproductive Medicine Center of a tertiary referral hospital. A total of 231 couples with male infertility due to incomplete necrozoospermia underwent 342 ICSI cycles with freshly ejaculated sperm (ICSI-ejaculated) and 182 cycles with testicular sperm (ICSI-TESE). Results: Overall 1624 MII oocytes were injected in the ICSI-ejaculated group with a fertilisation rate of 60.8%, while in ICSI- TESE cycles the fertilisation rate was 59.6% in 874 MII oocytes. The cleavage rate was higher in ICSI-ejaculated cycles than in ICSI-TESE cycles (96.3% versus 92.9%; p = 0.004). However, the pregnancy and implantation rates per cycle were significantly higher in the ICSI-TESE group (67/182, 36.8% versus 68/342, 19.9% (p = 0.0001); and 23.7% versus 12.7% (p = 0.0001), respectively). The miscarriage rate was similar (ICSI-ejaculated 26.5% versus ICSI-TESE 17.9%, p = 0.301). Live birth rate per cycle in the ICSI-ejaculated group was significantly lower than in the ICSI-TESE (13.7% versus 28.6%, p = 0.0001). Conclusions: In cases of persistent necrozoospermia, testicular sperm should be favoured over ejaculated sperm. These data call for more research to understand the pathophysiology of refractory necrozoospermia.

KW - Intracytoplasmic sperm injection (ICSI)

KW - Male infertility

KW - Necrozoospermia

KW - Testicular sperm extraction (TESE)

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