Idarubicin and cytosine arabinoside in the induction and maintenance therapy of high-risk myelodysplastic syndromes

Rosangela Invernizzi, Alessandro Pecci, Giuseppe Rossi, Anna Maria Pelizzari, Marcello Giusto, Carmine Tinelli, Edoardo Ascari

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Objective. Recently, the results of a few pilot studies have shown the efficacy of the association of idarubicin (IDA) and cytosine arabinoside (Ara-C), already successfully employed in acute myeloid leukemia (AML), for remission induction in patients with myelodysplastic syndrome (MDS). We set out to evaluate in a multicenter study the efficacy and tolerability of an intensive therapy with IDA and Ara-C in patients with RAEB and RAEB-t, the rate and duration of CR and the overall survival in adults treated with full doses and in the elderly treated with lower doses; furthermore, we investigated the efficacy of low-dose maintenance chemotherapy. Methods. Pretreated adult patients with de nova RAEB and RAEB- t, meeting at least one of the following criteria, were included: neutrophils <0.5 x 109/L or moderate neutropenia with infectious episodes, platelets <30 x 109/L or moderate thrombocytopenia but with bleeding symptoms, transfusion > 4 red cell units/months, rapid increase of bone marrow blasts. Induction treatment consisted of a cycle with IDA and Ara-C. Adult patients less than 65 years old were treated with the following doses: Ara-C 1 g/m2/day i.v. 6-hour infusion, on days 1-4, IDA 10 mg/m2/day i.v., on days 1-3. Elderly patients (≤ 65 yrs) were treated with lower doses: Ara-C 1 g/m2/day 6 hours infusion, on days 1 and 2, IDA 10 mg/m2/day i.v., on clays 1 and 2. Responders followed a consolidation course identical to induction. Results. From February 1994 to February 1997, 25 patients were enrolled, 20 males and 5 females aged between 22 and 76, 10 were ≤ 65 years old, 7 had RAEB and 18 had RAEB-t. Twelve cases (48%) achieved complete remission (CR), 7 cases (28%) achieved partial remission, 4 patients were resistant and two patients (8%) died during the aplastic phase. A significantly higher CR rate was found in younger patients (p = 0.036), while gender, FAB subtype, presence of Auer rods, cytogenetic findings, and the interval from diagnosis to treatment did not significantly influence CR achievement. Interpretation and Conclusions. Our results show that in de nova RAEB and RAEB-t, the employed treatment with IDA and Ara-C is associated with satisfactory frequency of response with acceptable toxicity.

Original languageEnglish
Pages (from-to)9-12
Number of pages4
JournalHaematologica
Volume82
Issue numberSUPPL.5
Publication statusPublished - Sep 1997

Keywords

  • Acute myeloid leukemia
  • Chemotherapy
  • Cytosine arabinoside
  • Idarubicin

ASJC Scopus subject areas

  • Hematology

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