Identification and characterization of a new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes

Mariagrazia Perilli; Bibiana Caporale; Giuseppe Celenza; Cristina Pellegrini; Jean Denis Docquier; Marilina Mezzatesta; Gian Maria Rossolini; A. Stefani; Gianfranco Amicosante

doi:10.1128/AAC.00083-07

Identification and characterization of a new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes

Mariagrazia Perilli, Bibiana Caporale, Giuseppe Celenza, Cristina Pellegrini, Jean Denis Docquier, Marilina Mezzatesta, Gian Maria Rossolini, A. Stefani, Gianfranco Amicosante

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article › peer-review

Abstract

A new natural IND-type metallo-β-lactamase variant, IND-5, was identified in a clinical isolate of Chryseobacterium indologenes. IND-5 shared 92.8% and 92.4% amino acid homology with IND-1 and IND-3, respectively. Purified enzyme (pI = 8.8, M _r = 25,000) was able to hydrolyze penicillins, some narrow- and expanded-spectrum cephalosporins, and carbapenems but not monobactams.

Original language	English
Pages (from-to)	2988-2990
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	51
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00083-07
Publication status	Published - Aug 2007

ASJC Scopus subject areas

Pharmacology (medical)

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Identification and characterization of a new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. / Perilli, Mariagrazia; Caporale, Bibiana; Celenza, Giuseppe; Pellegrini, Cristina; Docquier, Jean Denis; Mezzatesta, Marilina; Rossolini, Gian Maria; Stefani, A.; Amicosante, Gianfranco.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 8, 08.2007, p. 2988-2990.

Research output: Contribution to journal › Article › peer-review

Perilli, Mariagrazia ; Caporale, Bibiana ; Celenza, Giuseppe ; Pellegrini, Cristina ; Docquier, Jean Denis ; Mezzatesta, Marilina ; Rossolini, Gian Maria ; Stefani, A. ; Amicosante, Gianfranco. / Identification and characterization of a new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes. In: Antimicrobial Agents and Chemotherapy. 2007 ; Vol. 51, No. 8. pp. 2988-2990.

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AU - Celenza, Giuseppe

AU - Pellegrini, Cristina

AU - Docquier, Jean Denis

AU - Mezzatesta, Marilina

AU - Rossolini, Gian Maria

AU - Stefani, A.

AU - Amicosante, Gianfranco

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