Identification and characterization of a new metallo-β-lactamase, IND-5, from a clinical isolate of Chryseobacterium indologenes

Mariagrazia Perilli, Bibiana Caporale, Giuseppe Celenza, Cristina Pellegrini, Jean Denis Docquier, Marilina Mezzatesta, Gian Maria Rossolini, A. Stefani, Gianfranco Amicosante

Research output: Contribution to journalArticlepeer-review

Abstract

A new natural IND-type metallo-β-lactamase variant, IND-5, was identified in a clinical isolate of Chryseobacterium indologenes. IND-5 shared 92.8% and 92.4% amino acid homology with IND-1 and IND-3, respectively. Purified enzyme (pI = 8.8, M r = 25,000) was able to hydrolyze penicillins, some narrow- and expanded-spectrum cephalosporins, and carbapenems but not monobactams.

Original languageEnglish
Pages (from-to)2988-2990
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number8
DOIs
Publication statusPublished - Aug 2007

ASJC Scopus subject areas

  • Pharmacology (medical)

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