Identification and characterization of a novel member of the dystrobrevin gene family

Annibale Alessandro Puca, Vincenzo Nigro, Giulio Piluso, Angela Belsito, Simone Sampaolo, Nandita Quaderi, Elena Rossi, Giuseppe Di Iorio, Andrea Ballabio, Brunella Franco

Research output: Contribution to journalArticlepeer-review

Abstract

A new member of the dystrobrevin gene family was identified using a bioinformatics approach. Sequence analysis indicates that this gene, named DTN-B, is highly homologous to the rabbit A0, the previously described dystrobrevin (DTN), Torpedo 87 kDa and to the C-terminus of dystrophin. The coiled-coil domain, shown to be the site of interaction between dystrobrevins and dystrophin, is highly conserved. Immunostaining studies indicate that DTN-B and DTN expression is absent in affected muscle fibers from DMD patients and carriers.

Original languageEnglish
Pages (from-to)7-13
Number of pages7
JournalFEBS Letters
Volume425
Issue number1
DOIs
Publication statusPublished - Mar 20 1998

Keywords

  • Dystrobrevin
  • Dystrobrevin B
  • Dystrophin associated protein
  • Monoclonal antibody A0

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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