TY - JOUR
T1 - Identification and characterization of a novel member of the dystrobrevin gene family
AU - Puca, Annibale Alessandro
AU - Nigro, Vincenzo
AU - Piluso, Giulio
AU - Belsito, Angela
AU - Sampaolo, Simone
AU - Quaderi, Nandita
AU - Rossi, Elena
AU - Di Iorio, Giuseppe
AU - Ballabio, Andrea
AU - Franco, Brunella
PY - 1998/3/20
Y1 - 1998/3/20
N2 - A new member of the dystrobrevin gene family was identified using a bioinformatics approach. Sequence analysis indicates that this gene, named DTN-B, is highly homologous to the rabbit A0, the previously described dystrobrevin (DTN), Torpedo 87 kDa and to the C-terminus of dystrophin. The coiled-coil domain, shown to be the site of interaction between dystrobrevins and dystrophin, is highly conserved. Immunostaining studies indicate that DTN-B and DTN expression is absent in affected muscle fibers from DMD patients and carriers.
AB - A new member of the dystrobrevin gene family was identified using a bioinformatics approach. Sequence analysis indicates that this gene, named DTN-B, is highly homologous to the rabbit A0, the previously described dystrobrevin (DTN), Torpedo 87 kDa and to the C-terminus of dystrophin. The coiled-coil domain, shown to be the site of interaction between dystrobrevins and dystrophin, is highly conserved. Immunostaining studies indicate that DTN-B and DTN expression is absent in affected muscle fibers from DMD patients and carriers.
KW - Dystrobrevin
KW - Dystrobrevin B
KW - Dystrophin associated protein
KW - Monoclonal antibody A0
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U2 - 10.1016/S0014-5793(98)00097-0
DO - 10.1016/S0014-5793(98)00097-0
M3 - Article
C2 - 9540997
AN - SCOPUS:0032549565
VL - 425
SP - 7
EP - 13
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1
ER -