Identification and Clinical Characterization of Adult Patients with Multigenerational Diabetes Mellitus

Ornella Ludovico, Massimo Carella, Luigi Bisceglia, Giorgio Basile, Sandra Mastroianno, Antonio Palena, Salvatore De Cosmo, Massimiliano Copetti, Sabrina Prudente, Vincenzo Trischitta

Research output: Contribution to journalArticlepeer-review

Abstract

Background Some patients diagnosed as having type 2 diabetes mellitus (T2DM) are, instead, affected by multigenerational diabetes whose clinical characteristics are mostly undefined. Objective1. To identify among patients who had been previously defined as affected by T2DM those, in fact, affected by multigenerational diabetes; 2. After excluding patients carrying the most common MODY genes and mitochondrial mutations, we compared clinical features of remaining patients with those of patients with T2DM. Methods Among 2,583 consecutive adult patients who had been defined as affected by T2DM, we looked for those with diabetes in 3 consecutive generations. All probands were screened for mutations in six MODY genes (HNF4A, GCK, HNF1A, PDX1, HNF1B and NeuroD1) and for the A3243G mitochondrial mutation. After excluding patients with mutations in one of such genes, we compared clinical features of the remaining 67 patients (2.6% of the whole initial sample) affected by multigenerational "familial diabetes of the adulthood" (FDA) and of their diabetic relatives (n = 63) to those with T2DM (n = 1,028) by generalized hierarchical linear models followed by pairwise comparisons. Results Age, age at diagnosis, proportion of hypertension (all p

Original languageEnglish
Article numbere0135855
JournalPLoS One
Volume10
Issue number8
DOIs
Publication statusPublished - Aug 19 2015

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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