Identification and consequences of galectin-3 expression in pituitary tumors

A. Righi, L. Jin, S. Zhang, G. Stilling, B. W. Scheithauer, K. Kovacs, R. V. Lloyd

Research output: Contribution to journalArticle

Abstract

Although the mechanisms regulating pituitary tumor development and progression are still unclear, new information on the molecular mechanisms involved in the pathogenesis of human pituitary tumors have accumulated. Recent evidence suggests that galectin-3 plays an important role in pituitary tumorigenesis and in tumor progression. Galectin-3 is expressed in a variety of tumors and the intensity of expression and localization depend on tumor progression, invasiveness and metastatic potential. Galectin-3 expression has been used as a potential diagnostic and/or prognostic marker in a variety of neoplasms. This review summarizes existing information regarding the structural and functional properties of galectin-3 protein as well as the LGALS3 gene in pituitary tumorigenesis. Given its role in pituitary tumor cell proliferation and in apoptosis, galectin-3 may be a target for the treatment of aggressive pituitary tumors.

Original languageEnglish
Pages (from-to)8-14
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume326
Issue number1-2
DOIs
Publication statusPublished - Sep 2010

Keywords

  • ACTH adenoma
  • Folliculo-stellate cells
  • Galectin-3
  • Pituitary
  • PRL adenoma
  • Tumor

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

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  • Cite this

    Righi, A., Jin, L., Zhang, S., Stilling, G., Scheithauer, B. W., Kovacs, K., & Lloyd, R. V. (2010). Identification and consequences of galectin-3 expression in pituitary tumors. Molecular and Cellular Endocrinology, 326(1-2), 8-14. https://doi.org/10.1016/j.mce.2010.04.026