Identification, gene structure, and expression of human frizzled-3 (FZD3)

Cinzia F. Sala, Elisa Formenti, Georg C. Terstappen, Andrea Caricasole

Research output: Contribution to journalArticle

Abstract

We report the identification, genomic structure, chromosomal localization, and expression analysis of human frizzled-3 (FZD3), a 7-transmembrane receptor belonging to the frizzled family. The cDNA obtained from adult human brain shows 91% identity at the nucleotide level and 98% at the amino acid level to mouse frizzled-3 (fzd3). The FZD3 locus is located on chromosome 8p21, spans 48 Kb and its coding sequence is distributed in 6 exons intercalated by 5 introns. FZD3 is expressed in all analyzed human tissues, with quantitatively higher expression in the CNS and in urogenital structures. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)27-34
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume273
Issue number1
DOIs
Publication statusPublished - Jun 24 2000

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Chromosomes
Introns
Exons
Brain
Nucleotides
Complementary DNA
Genes
Tissue
Gene Expression
Amino Acids

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Identification, gene structure, and expression of human frizzled-3 (FZD3). / Sala, Cinzia F.; Formenti, Elisa; Terstappen, Georg C.; Caricasole, Andrea.

In: Biochemical and Biophysical Research Communications, Vol. 273, No. 1, 24.06.2000, p. 27-34.

Research output: Contribution to journalArticle

Sala, Cinzia F. ; Formenti, Elisa ; Terstappen, Georg C. ; Caricasole, Andrea. / Identification, gene structure, and expression of human frizzled-3 (FZD3). In: Biochemical and Biophysical Research Communications. 2000 ; Vol. 273, No. 1. pp. 27-34.
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