Identification of a gene that reverses the immortal phenotype of a subset of cells and is a member of a novel family of transcription factor- like genes

M. J. Bertram, N. G. Bérubé, X. Hang-Swanson, Q. Ran, J. K. Leung, S. Bryce, K. Spurgers, R. J. Bick, A. Baldini, Y. Ning, L. J. Clark, E. K. Parkinson, J. C. Barrett, J. R. Smith, O. M. Pereira-Smith

Research output: Contribution to journalArticlepeer-review

Abstract

Based on the dominance of cellular senescence over immortality, immortal human cell lines have been assigned to four complementation groups for indefinite division. Human chromosomes carrying senescence genes have been identified, including chromosome 4. We report the cloning and identification of a gene, mortality factor 4 (MORF 4), which induces a senescent-like phenotype in immortal cell lines assigned to complementation group B with concomitant changes in two markers for senescence. MORF 4 is a member of a novel family of genes with transcription factor-like motifs. We present here the sequences of the seven family members, their chromosomal locations, and a partial characterization of the three members that are expressed. Elucidation of the mechanism of action of these genes should enhance our understanding of growth regulation and cellular aging.

Original languageEnglish
Pages (from-to)1479-1485
Number of pages7
JournalMolecular and Cellular Biology
Volume19
Issue number2
Publication statusPublished - Feb 1999

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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