Identification of a MAGE-1 peptide recognized by cytolytic T lymphocytes on HLA-B*5701 tumors

V. Corbière, H. Nicolay, V. Russo, V. Stroobant, V. Brichard, T. Boon, P. Van Der Bruggen

Research output: Contribution to journalArticlepeer-review

Abstract

'Cancer germline' genes such as those of the MAGE family are expressed in many tumors and in male germline cells but are silent in normal tissues. They encode shared tumor-specific antigens that have been used in therapeutic vaccination trials of cancer patients. We report the identification of a new MAGE-1-encoded peptide that is recognized by a cytolytic T-lympnocyte (CTL) clone on human leukocyte antigen (HLA)-B*5701. The sequence of the peptide, corresponding to position 102-112 of the MAGE-1 protein sequence, is ITKKVADLVGF. When tumor cells expressing MAGE-1 were transfected with HLA-B*5701, they were lyzed by the CTL clone, indicating that the peptide is processed in tumor cells and can, therefore, be used as a target for anti-tumoral vaccination.

Original languageEnglish
Pages (from-to)453-457
Number of pages5
JournalTissue Antigens
Volume63
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • Antigen
  • Cytolytic T lymphocyte
  • Dendritic cells
  • HLA-B57
  • MAGE
  • Peptide
  • Poxvirus
  • Tumor

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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