IDENTIFICATION OF A MATHEMATICAL MODEL FOR THE INVESTIGATION OF THE DIFFERENCES BETWEEN MONOFERRIC AND DIFFERRIC TRANSFERRIN IN MAN.

C. Larizza, M. Stefanelli, G. Barosi, M. Cazzola, P. Palestra

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The internal iron exchange is mediated by transferrin, a carrier protein which has two iron binding sites. Recent studies, both 'in vitro' and in animals, showed that a transferrin molecule bearing two iron atoms (diferric transferrin) delivers its iron to the tissues faster than a molecule bearing one iron atom (monoferric transferrin). We investigated the same phenomenon in man by using radioiron-labelled transferrin species. It consisted in the injection of two differently labelled samples of transferrin: one partially saturated with radioiron (a mixture of mono and diferric transferrin) and the other completely saturated (diferric transferrin). The results obtained in normal subjects and patients with disorders of iron metabolism and erythropoiesis seem to indicate new interesting mechanisms of regulation of the iron transport from transferrin to tissues.

Original languageEnglish
Title of host publicationIFAC Proceedings Series
PublisherPergamon Press
Pages1397-1402
Number of pages6
Edition7
ISBN (Print)0080325424
Publication statusPublished - 1985

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Mathematical models
Iron
Bearings (structural)
Tissue
Atoms
Molecules
Binding sites
Metabolism
Animals

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Larizza, C., Stefanelli, M., Barosi, G., Cazzola, M., & Palestra, P. (1985). IDENTIFICATION OF A MATHEMATICAL MODEL FOR THE INVESTIGATION OF THE DIFFERENCES BETWEEN MONOFERRIC AND DIFFERRIC TRANSFERRIN IN MAN. In IFAC Proceedings Series (7 ed., pp. 1397-1402). Pergamon Press.

IDENTIFICATION OF A MATHEMATICAL MODEL FOR THE INVESTIGATION OF THE DIFFERENCES BETWEEN MONOFERRIC AND DIFFERRIC TRANSFERRIN IN MAN. / Larizza, C.; Stefanelli, M.; Barosi, G.; Cazzola, M.; Palestra, P.

IFAC Proceedings Series. 7. ed. Pergamon Press, 1985. p. 1397-1402.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Larizza, C, Stefanelli, M, Barosi, G, Cazzola, M & Palestra, P 1985, IDENTIFICATION OF A MATHEMATICAL MODEL FOR THE INVESTIGATION OF THE DIFFERENCES BETWEEN MONOFERRIC AND DIFFERRIC TRANSFERRIN IN MAN. in IFAC Proceedings Series. 7 edn, Pergamon Press, pp. 1397-1402.
Larizza C, Stefanelli M, Barosi G, Cazzola M, Palestra P. IDENTIFICATION OF A MATHEMATICAL MODEL FOR THE INVESTIGATION OF THE DIFFERENCES BETWEEN MONOFERRIC AND DIFFERRIC TRANSFERRIN IN MAN. In IFAC Proceedings Series. 7 ed. Pergamon Press. 1985. p. 1397-1402
Larizza, C. ; Stefanelli, M. ; Barosi, G. ; Cazzola, M. ; Palestra, P. / IDENTIFICATION OF A MATHEMATICAL MODEL FOR THE INVESTIGATION OF THE DIFFERENCES BETWEEN MONOFERRIC AND DIFFERRIC TRANSFERRIN IN MAN. IFAC Proceedings Series. 7. ed. Pergamon Press, 1985. pp. 1397-1402
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