Identification of a minimal region of loss on chromosome 6q27 associated with poor survival of high-risk neuroblastoma patients

Research output: Contribution to journalArticlepeer-review

Abstract

Patients with high-risk neuroblastoma (HR-NB) often initially respond to therapy, but afterward they become resistant and disease recurred. Unfortunately, it does not exist one or more specific chromosome defects associated with relapse or refractory NB. Recently, genomic evidence from primary tumors indicated that the distal region of chromosome 6q is loss in HR-NB patients with fatal outcome. We identified a minimal common region of loss of chromosome 6q27 spanning an area of 2.09 Mb by high-resolution DNA copy number data of a small cohort of HR-NB samples carrying 6q loss. This region of loss harbored five genes T, SFT2D1, RPS6KA2, FGFR1OP, and UNC93A. We found that low SFT2D1, RPS6KA2, and FGFR1OP gene expression predicted poor outcome in HR-NB patients using public R2 Platform. Further functional studies will be essential to confirm the presumed tumor suppressor gene(s) located within 6q27 region. These results suggest that SFT2D1, RPS6KA2, and FGFR1OP genes may be responsible for poor prognosis of HR-NB tumors with 6q27 loss, and their haploinsufficiency may be crucial in accelerating tumor progression.

Original languageEnglish
Pages (from-to)391-399
Number of pages9
JournalCancer Biology and Therapy
Volume21
Issue number5
DOIs
Publication statusPublished - May 3 2020

Keywords

  • Adolescent
  • Adult
  • Aged
  • Child
  • Chromosome Mapping/methods
  • Chromosomes, Human, Pair 6/genetics
  • Cohort Studies
  • Comparative Genomic Hybridization/methods
  • Databases, Genetic/statistics & numerical data
  • Gene Expression Regulation, Neoplastic
  • Genes, Tumor Suppressor
  • Humans
  • Loss of Heterozygosity
  • Middle Aged
  • Neuroblastoma/genetics
  • Survival Rate
  • Young Adult

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