Abstract
Background: During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with bla NDM-4 gene were investigated. Results: The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and β-lactams. The strains produced the NDM-4 carbapenemase and the bla NDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). Conclusions: This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.
Original language | English |
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Article number | 148 |
Journal | BMC Microbiology |
Volume | 14 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jun 7 2014 |
Keywords
- Carbapenemases
- Class 1 integron
- E.coli
- ST405
ASJC Scopus subject areas
- Microbiology (medical)
- Microbiology
- Medicine(all)