Identification of a New Delhi metallo-β-lactamase-4 (NDM-4)-producing Escherichia coli in Italy

Erika Coppo; Valerio Del Bono; Francesco Ventura; Marco Camera; Giovanni Orengo; Claudio Viscoli; Anna Marchese

doi:10.1186/1471-2180-14-148

Identification of a New Delhi metallo-β-lactamase-4 (NDM-4)-producing Escherichia coli in Italy

Erika Coppo, Valerio Del Bono, Francesco Ventura, Marco Camera, Giovanni Orengo, Claudio Viscoli, Anna Marchese

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

Background: During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with bla _NDM-4 gene were investigated. Results: The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and β-lactams. The strains produced the NDM-4 carbapenemase and the bla _NDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). Conclusions: This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.

Original language	English
Article number	148
Journal	BMC Microbiology
Volume	14
Issue number	1
DOIs	https://doi.org/10.1186/1471-2180-14-148
Publication status	Published - Jun 7 2014

Keywords

Carbapenemases
Class 1 integron
E.coli
ST405

ASJC Scopus subject areas

Microbiology (medical)
Microbiology
Medicine(all)

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10.1186/1471-2180-14-148

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title = "Identification of a New Delhi metallo-β-lactamase-4 (NDM-4)-producing Escherichia coli in Italy",

abstract = "Background: During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with bla NDM-4 gene were investigated. Results: The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and β-lactams. The strains produced the NDM-4 carbapenemase and the bla NDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). Conclusions: This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.",

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AU - Coppo, Erika

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AU - Camera, Marco

AU - Orengo, Giovanni

AU - Viscoli, Claudio

AU - Marchese, Anna

PY - 2014/6/7

Y1 - 2014/6/7

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AB - Background: During June-July 2012, six imipenem-resistant Escherichia coli isolates were isolated from two patients hospitalized in a ward of one large tertiary-care hospital in Genoa, Italy. Genetic features associated with bla NDM-4 gene were investigated. Results: The isolates exhibited the same PFGE profile and a multidrug-resistant (MDR) phenotype to aminoglycosides, fluoroquinolones, and β-lactams. The strains produced the NDM-4 carbapenemase and the bla NDM-4 gene was part of the variable region of a class 1 integron. MLST analysis revealed that all isolates belonged to sequence type 405 (ST405). Conclusions: This is the first report on the emergence of an MDR strain of E.coli producing the NDM-4 MBL in Italy.

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Identification of a New Delhi metallo-β-lactamase-4 (NDM-4)-producing Escherichia coli in Italy

Abstract

Keywords

ASJC Scopus subject areas

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