Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25

Annalisa Frattini, Sara Faranda, Luca Bagnasco, Cristina Patrosso, Paola Nulli, Ileana Zucchi, Paolo Vezzoni

Research output: Contribution to journalArticle

Abstract

Four genes were mapped to the Xq24-25 region by searching the EST and the non-redundant database with short tracts of genomic sequences. These were random STSs present in the STS database or sequences derived from CpG islands (EagI-based STSs). One of the four matches corresponded to the full length transcript from the intronless glutamate dehydrogenase gene. The second was the human homolog of the bovine NADH ubiquinone oxidoreductase MWFE subunit gene (GDB symbol: NDUFA1). The other two, ZNF183 and ITBA4, were novel genes whose function cannot directly be inferred from their sequence analysis. However, a known motif, the C3HC4 Ring finger domain, shared by various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, is present at the C terminus of the ubiquitously expressed ZNF183 gene. ITBA4 is expressed at various levels in different tissues and is alternatively processed in brain. Similarity search did not detect any significant match in databases. These results, together with others previously reported by our laboratory, suggest that comparison of genomic and transcribed sequences which are continuously accumulating in databases, can provide 'virtual' mapping of a substantial number of ESTs to the specific genomic region which the STSs have been derived from.

Original languageEnglish
Pages (from-to)291-298
Number of pages8
JournalGene
Volume192
Issue number2
DOIs
Publication statusPublished - Jun 19 1997

Keywords

  • Expressed sequence tag
  • NADH oxidoreductase
  • Sequence tagged site
  • Zinc finger

ASJC Scopus subject areas

  • Genetics

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    Frattini, A., Faranda, S., Bagnasco, L., Patrosso, C., Nulli, P., Zucchi, I., & Vezzoni, P. (1997). Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25. Gene, 192(2), 291-298. https://doi.org/10.1016/S0378-1119(97)00108-X