Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus

Susanna Chiocca, Adam Baker, Matt Cotten

Research output: Contribution to journalArticle

Abstract

We have developed a simple screening method to identify genes that mimic bcl-2 or adenovirus E1B 19K in enhancing cell survival after transfection and have used this method to identify such a gene in the avian adenovirus CELO. The gene encodes a novel 30-kDa nuclear protein, which we have named GAM-1, that functions comparably to Bcl-2 and adenovirus E1B 19K in blocking apoptosis. However, GAM-1 has no sequence homology to Bcl-2, E1B 19K, or any other known antiapoptotic proteins and thus defines a novel antiapoptotic function.

Original languageEnglish
Pages (from-to)3168-3177
Number of pages10
JournalJournal of Virology
Volume71
Issue number4
Publication statusPublished - 1997

ASJC Scopus subject areas

  • Immunology

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