Identification of a novel HLA-B allele - HLA-B*4902

F. Poli, E. Longhi, S. Frison, M. Scalamogna, L. Crespiatico, P. Bianchi, G. Sirchia

Research output: Contribution to journalArticlepeer-review

Abstract

We report herein the identification of HLA-B*4902. This new allele was identified in a Caucasian individual serologically typed as B49. The allele codifying for this antigen was not clearly detectable with polymerase chain reaction using sequence-specific primers (PCR-SSP) because of an atypical amplification pattern. DNA sequencing demonstrated the presence of a new variant due to two nucleotide substitutions (from G to C and from T to C) in exon 2 at nucleotides 309 and 311 respectively. These substitutions would result in a silent mutation and in one amino acid substitution from Ile to Thr, respectively.

Original languageEnglish
Pages (from-to)173-174
Number of pages2
JournalTissue Antigens
Volume57
Issue number2
DOIs
Publication statusPublished - 2001

Keywords

  • HLA-B*49
  • MHC

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

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