Identification of a novel HLA-B allele - HLA-B*4902

F. Poli, E. Longhi, S. Frison, M. Scalamogna, L. Crespiatico, P. Bianchi, G. Sirchia

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We report herein the identification of HLA-B*4902. This new allele was identified in a Caucasian individual serologically typed as B49. The allele codifying for this antigen was not clearly detectable with polymerase chain reaction using sequence-specific primers (PCR-SSP) because of an atypical amplification pattern. DNA sequencing demonstrated the presence of a new variant due to two nucleotide substitutions (from G to C and from T to C) in exon 2 at nucleotides 309 and 311 respectively. These substitutions would result in a silent mutation and in one amino acid substitution from Ile to Thr, respectively.

Original languageEnglish
Pages (from-to)173-174
Number of pages2
JournalTissue Antigens
Volume57
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

HLA-B Antigens
Substitution reactions
Nucleotides
Alleles
Amino Acid Substitution
DNA Sequence Analysis
Exons
Polymerase chain reaction
Antigens
Polymerase Chain Reaction
Amplification
Amino Acids
DNA
HLA-B*49:02 antigen
Silent Mutation

Keywords

  • HLA-B*49
  • MHC

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Identification of a novel HLA-B allele - HLA-B*4902. / Poli, F.; Longhi, E.; Frison, S.; Scalamogna, M.; Crespiatico, L.; Bianchi, P.; Sirchia, G.

In: Tissue Antigens, Vol. 57, No. 2, 2001, p. 173-174.

Research output: Contribution to journalArticle

Poli, F. ; Longhi, E. ; Frison, S. ; Scalamogna, M. ; Crespiatico, L. ; Bianchi, P. ; Sirchia, G. / Identification of a novel HLA-B allele - HLA-B*4902. In: Tissue Antigens. 2001 ; Vol. 57, No. 2. pp. 173-174.
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