Identification of a novel hla-drb1 allele: Drb1*1353

E. Longhi, S. Frison, Francesca Poli, D. Gaboardi, G. Ferrioli, M. Scalamogna

Research output: Contribution to journalArticlepeer-review

Abstract

In this report we describe a new HLA-DRB1 allele, DRB1*1353, which was initially recognized by a discrepancy between the results obtained with polymerase chain reaction using sequence-specific oligonucleotide (PCR-SSO) and sequence-specific primers (PCR-SSP). Sequence-based typing revealed sequence differences with other known HLA-DRB1 alleles. DRB1*1353 is identical to DRB1*13011 except for two nucleotide substitutions at nucleotide 84 (C(r)G) and at nucleotide 140 (T(r)A). These differences give rise to two amino acid substitutions at codons 28 and 47 from Asp to Glu and from Phe to Tyr, respectively.

Original languageEnglish
Pages (from-to)177-178
Number of pages2
JournalTissue Antigens
Volume61
Issue number2
DOIs
Publication statusPublished - Feb 1 2003

Keywords

  • HLA-DRB1
  • SBT

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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