Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 Region

Georg Buchner, Maria Teresa Bassi, Grazia Andolfi, Andrea Ballabio, Brunella Franco

Research output: Contribution to journalArticlepeer-review

Abstract

We report the identification of a new transcript homologous to the Drosophila staufen protein. This transcript, named STAU2 (HGMW-approved gene symbol and name), maps to the chromosome 8q13-q21 region. The full-length STAU2 cDNA is 4058 bp and contains an open reading frame of 479 amino acids. Analysis of the predicted protein product indicated the presence of three double-stranded RNA-binding domains. Best-fit analysis revealed a 48.5% similarity to the Drosophila protein and a 59.9% similarity to the recently described mammalian homolog hStau, indicating that at least two different transcripts with homologies to the fly protein are present in mammals.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalGenomics
Volume62
Issue number1
DOIs
Publication statusPublished - Nov 15 1999

ASJC Scopus subject areas

  • Genetics

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