Identification of a region within SEL1L protein required for tumour growth inhibition

Monica Cattaneo; Cristina Canton; Alberto Albertini; Ida Biunno

doi:10.1016/j.gene.2003.10.021

Identification of a region within SEL1L protein required for tumour growth inhibition

Monica Cattaneo, Cristina Canton, Alberto Albertini, Ida Biunno

IRCCS Multimedica

Research output: Contribution to journal › Article

Abstract

The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail.

Original language	English
Pages (from-to)	149-156
Number of pages	8
Journal	Gene
Volume	326
Issue number	1-2
DOIs	https://doi.org/10.1016/j.gene.2003.10.021
Publication status	Published - Feb 4 2004

Keywords

SEL1L deletion mutant
SEL1L family
TPR-like SEL-1 repeats

ASJC Scopus subject areas

Genetics

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Cattaneo, M., Canton, C., Albertini, A., & Biunno, I. (2004). Identification of a region within SEL1L protein required for tumour growth inhibition. Gene, 326(1-2), 149-156. https://doi.org/10.1016/j.gene.2003.10.021

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AU - Albertini, Alberto

AU - Biunno, Ida

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