Identification of a region within SEL1L protein required for tumour growth inhibition

Monica Cattaneo, Cristina Canton, Alberto Albertini, Ida Biunno

Research output: Contribution to journalArticle

Abstract

The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalGene
Volume326
Issue number1-2
DOIs
Publication statusPublished - Feb 4 2004

Keywords

  • SEL1L deletion mutant
  • SEL1L family
  • TPR-like SEL-1 repeats

ASJC Scopus subject areas

  • Genetics

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