Identification of a region within SEL1L protein required for tumour growth inhibition

Monica Cattaneo, Cristina Canton, Alberto Albertini, Ida Biunno

Research output: Contribution to journal › Article

17 Citations (Scopus)

Abstract

The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalGene
Volume326
Issue number1-2
DOIs
Publication statusPublished - Feb 4 2004

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Aptitude
Proline
Tail
Complementary DNA
Breast Neoplasms
Amino Acids
Cell Line
Growth
Neoplasms
Proteins
Ectopic Gene Expression
Inhibition (Psychology)

Keywords

  • SEL1L deletion mutant
  • SEL1L family
  • TPR-like SEL-1 repeats

ASJC Scopus subject areas

  • Genetics

Cite this

Identification of a region within SEL1L protein required for tumour growth inhibition. / Cattaneo, Monica; Canton, Cristina; Albertini, Alberto; Biunno, Ida.

In: Gene, Vol. 326, No. 1-2, 04.02.2004, p. 149-156.

Research output: Contribution to journal › Article

Cattaneo, M, Canton, C, Albertini, A & Biunno, I 2004, 'Identification of a region within SEL1L protein required for tumour growth inhibition', Gene, vol. 326, no. 1-2, pp. 149-156. https://doi.org/10.1016/j.gene.2003.10.021
Cattaneo M, Canton C, Albertini A, Biunno I. Identification of a region within SEL1L protein required for tumour growth inhibition. Gene. 2004 Feb 4;326(1-2):149-156. https://doi.org/10.1016/j.gene.2003.10.021
Cattaneo, Monica ; Canton, Cristina ; Albertini, Alberto ; Biunno, Ida. / Identification of a region within SEL1L protein required for tumour growth inhibition. In: Gene. 2004 ; Vol. 326, No. 1-2. pp. 149-156.
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