Identification of a region within SEL1L protein required for tumour growth inhibition

Monica Cattaneo, Cristina Canton, Alberto Albertini, Ida Biunno

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail.

Original languageEnglish
Pages (from-to)149-156
Number of pages8
JournalGene
Volume326
Issue number1-2
DOIs
Publication statusPublished - Feb 4 2004

Fingerprint

Aptitude
Proline
Tail
Complementary DNA
Breast Neoplasms
Amino Acids
Cell Line
Growth
Neoplasms
Proteins
Ectopic Gene Expression
Inhibition (Psychology)

Keywords

  • SEL1L deletion mutant
  • SEL1L family
  • TPR-like SEL-1 repeats

ASJC Scopus subject areas

  • Genetics

Cite this

Identification of a region within SEL1L protein required for tumour growth inhibition. / Cattaneo, Monica; Canton, Cristina; Albertini, Alberto; Biunno, Ida.

In: Gene, Vol. 326, No. 1-2, 04.02.2004, p. 149-156.

Research output: Contribution to journalArticle

Cattaneo, Monica ; Canton, Cristina ; Albertini, Alberto ; Biunno, Ida. / Identification of a region within SEL1L protein required for tumour growth inhibition. In: Gene. 2004 ; Vol. 326, No. 1-2. pp. 149-156.
@article{b5c5ee2bbbb74439be406f3485fb9142,
title = "Identification of a region within SEL1L protein required for tumour growth inhibition",
abstract = "The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail.",
keywords = "SEL1L deletion mutant, SEL1L family, TPR-like SEL-1 repeats",
author = "Monica Cattaneo and Cristina Canton and Alberto Albertini and Ida Biunno",
year = "2004",
month = "2",
day = "4",
doi = "10.1016/j.gene.2003.10.021",
language = "English",
volume = "326",
pages = "149--156",
journal = "Gene",
issn = "0378-1119",
publisher = "Elsevier B.V.",
number = "1-2",

}

TY - JOUR

T1 - Identification of a region within SEL1L protein required for tumour growth inhibition

AU - Cattaneo, Monica

AU - Canton, Cristina

AU - Albertini, Alberto

AU - Biunno, Ida

PY - 2004/2/4

Y1 - 2004/2/4

N2 - The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail.

AB - The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail.

KW - SEL1L deletion mutant

KW - SEL1L family

KW - TPR-like SEL-1 repeats

UR - http://www.scopus.com/inward/record.url?scp=0347948145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347948145&partnerID=8YFLogxK

U2 - 10.1016/j.gene.2003.10.021

DO - 10.1016/j.gene.2003.10.021

M3 - Article

C2 - 14729273

AN - SCOPUS:0347948145

VL - 326

SP - 149

EP - 156

JO - Gene

JF - Gene

SN - 0378-1119

IS - 1-2

ER -