TY - JOUR
T1 - Identification of a region within SEL1L protein required for tumour growth inhibition
AU - Cattaneo, Monica
AU - Canton, Cristina
AU - Albertini, Alberto
AU - Biunno, Ida
PY - 2004/2/4
Y1 - 2004/2/4
N2 - The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail.
AB - The ectopic expression of the entire SEL1L cDNA significantly reduces the proliferate activity and aggressive behavior of the human breast carcinoma cell line MCF-7. However, the mechanism responsible for this biological effect remains unclear. A study was initiated to define those regions within SEL1L conferring such antiproliferative properties. Here we report that the region between amino acid residues 659-794 contains a functionally relevant domain since a deletion mutant impairs SEL1L's ability to suppress tumor cell growth. This region contains the Hrd3 motif, tetratricopeptide (TPR)-like SEL1 repeat, a transmembrane region, and a proline-rich tail.
KW - SEL1L deletion mutant
KW - SEL1L family
KW - TPR-like SEL-1 repeats
UR - http://www.scopus.com/inward/record.url?scp=0347948145&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0347948145&partnerID=8YFLogxK
U2 - 10.1016/j.gene.2003.10.021
DO - 10.1016/j.gene.2003.10.021
M3 - Article
C2 - 14729273
AN - SCOPUS:0347948145
VL - 326
SP - 149
EP - 156
JO - Gene
JF - Gene
SN - 0378-1119
IS - 1-2
ER -